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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Zimmermann, A; Madeo, F; Diwan, A; Sadoshima, J; Sedej, S; Kroemer, G; Abdellatif, M.
Metabolic control of mitophagy.
Eur J Clin Invest. 2024; 54(4):e14138
Doi: 10.1111/eci.14138
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Abdellatif Mahmoud
- Zimmermann Andreas
- Co-authors Med Uni Graz
- Sedej Simon
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- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Mitochondrial dysfunction is a major hallmark of ageing and related chronic disorders. Controlled removal of damaged mitochondria by the autophagic machinery, a process known as mitophagy, is vital for mitochondrial homeostasis and cell survival. The central role of mitochondria in cellular metabolism places mitochondrial removal at the interface of key metabolic pathways affecting the biosynthesis or catabolism of acetyl-coenzyme A, nicotinamide adenine dinucleotide, polyamines, as well as fatty acids and amino acids. Molecular switches that integrate the metabolic status of the cell, like AMP-dependent protein kinase, protein kinase A, mechanistic target of rapamycin and sirtuins, have also emerged as important regulators of mitophagy. In this review, we discuss how metabolic regulation intersects with mitophagy. We place special emphasis on the metabolic regulatory circuits that may be therapeutically targeted to delay ageing and mitochondria-associated chronic diseases. Moreover, we identify outstanding knowledge gaps, such as the ill-defined distinction between basal and damage-induced mitophagy, which must be resolved to boost progress in this area.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Mitophagy - physiology
- Mitochondria - physiology
- Autophagy - administration & dosage
- Homeostasis - administration & dosage
- Find related publications in this database (Keywords)
- acetyl-CoA
- ageing
- ageing-related disease
- AMPK
- metabolism
- mitophagy
- NAD
- spermidine