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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Gauckler, P; Zitt, E; Regele, H; Eller, K; Säemann, MD; Lhotta, K; Neumann, I; Rudnicki, M; Odler, B; Kronbichler, A; Zschocke, J; Windpessl, M.
[Diagnosis and treatment of focal-segmental glomerulosclerosis-2023].
Wien Klin Wochenschr. 2023; 135(Suppl 5): 638-647. Doi: 10.1007/s00508-023-02260-x [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Co-Autor*innen der Med Uni Graz
Eller Kathrin
Odler Balazs
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Abstract:
The histopathological term focal-segmental glomerulosclerosis comprises different pathogenic processes with the unifying features of a high proteinuria and the name-giving glomerular lesion pattern seen on light microscopy. A differentiation according to the underlying cause into primary, secondary and genetic forms is therefore of utmost importance. The pathogenesis of primary focal-segmental glomerulosclerosis remains unknown but, like minimal-change disease, an autoimmune-mediated process leading to podocyte damage is assumed. Consequently, the unifying term "podocytopathy" is increasingly being used for both entities. Supportive treatment measures to preserve kidney function are important in all subtypes. In contrast, immunosuppressive treatment is only indicated in primary focal-segmental glomerulosclerosis. Steroid-dependence, steroid-resistance and frequently relapsing disease often complicate disease management and necessitate alternative treatment strategies. Here, the Austrian Society of Nephrology (ÖGN) provides consensus recommendations on how to best diagnose and manage patients with focal-segmental glomerulosclerosis.
Find related publications in this database (using NLM MeSH Indexing)
Humans - administration & dosage
Glomerulosclerosis, Focal Segmental - diagnosis, therapy
Austria - administration & dosage
Consensus - administration & dosage
Disease Management - administration & dosage

Find related publications in this database (Keywords)
Focal-segmental glomerulosclerosis
Proteinuria
Podocytopathy
Glucocorticoids
Rituximab
Supportive therapy
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