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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Mihalic, ZN; Kloimböck, T; Cosic-Mujkanovic, N; Valadez-Cosmes, P; Maitz, K; Kindler, O; Wadsack, C; Heinemann, A; Marsche, G; Gauster, M; Pollheimer, J; Kargl, J.
Myeloperoxidase enhances the migration and invasion of human choriocarcinoma JEG-3 cells.
Redox Biol. 2023; 67:102885 Doi: 10.1016/j.redox.2023.102885 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Juvan Zala Nikita
Kargl Julia
Co-Autor*innen der Med Uni Graz
Cosic Mujkanovic Nejra
Gauster Martin
Heinemann Akos
Kindler Oliver
Kloimböck Teresa
Maitz Kathrin
Marsche Gunther
Valadez Cosmes Paulina
Wadsack Christian
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Abstract:
Myeloperoxidase (MPO) is one of the most abundant proteins in neutrophil granules. It catalyzes the production of reactive oxygen species, which are important in inflammation and immune defense. MPO also binds to several proteins, lipids, and DNA to alter their function. MPO is present at the feto-maternal interface during pregnancy, where neutrophils are abundant. In this study, we determined the effect of MPO on JEG-3 human choriocarcinoma cells as a model of extravillous trophoblasts (EVTs) during early pregnancy. We found that MPO was internalized by JEG-3 cells and localized to the cytoplasm and nuclei. MPO internalization and activity enhanced JEG-3 cell migration and invasion, whereas this effect was impaired by pre-treating cells with heparin, to block cellular uptake, and MPO-activity inhibitor 4-ABAH. This study identifies a novel mechanism for the effect of MPO on EVT function during normal pregnancy and suggests a potential role of MPO in abnormal pregnancies.
Find related publications in this database (using NLM MeSH Indexing)
Female - administration & dosage
Humans - administration & dosage
Pregnancy - administration & dosage
Cell Line, Tumor - administration & dosage
Choriocarcinoma - metabolism, pathology
Peroxidase - metabolism
Proteins - metabolism
Trophoblasts - metabolism

Find related publications in this database (Keywords)
Neutrophils
Myeloperoxidase
Trophoblasts
Decidua basalis
Cell migration
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