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Spicher, MT; von der Haar-Leistl, D; Schwaminger, SP; Linder, S; Berensmeier, S.
Scalable diafiltration process for the purification of a colloidal dispersion of ultrasmall iron (oxyhydr)oxide-based nanoparticles
SEP PURIF TECHNOL. 2023; 325: 124703 Doi: 10.1016/j.seppur.2023.124703
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Co-Autor*innen der Med Uni Graz
Schwaminger Sebastian
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Abstract:
The process description for large-scale production of iron (oxyhydr)oxide nanoparticles is currently receiving greater attention, with cost-effective industrial production usually crucial for economic application. In this context, the purification step is often price-determining in the production process. Dialysis as membrane-assisted purification is one of the most widely used methods in the case of iron (oxyhydr)oxide nanoparticles but has very limited suitability for large-scale production. This study aims to demonstrate for the first time that cross-flow filtration is a suitable alternative for the industrial production of ultrasmall iron (oxyhydr)oxide nanoparticles. This study includes the development of a concentration and diafiltration process for ultrasmall iron (oxyhydr) oxide nanoparticles on a laboratory scale, upscaling for the purification of 75 kg nanoparticle suspension, and comparison with dialysis purification.In summary, the optimized filtration process is characterized by a consistent and high product quality and high product yield, comparable to dialysis purification and suitable for pilot-scale production. Finally, the results demonstrated that the developed process is an economically attractive alternative to dialysis. The processing time is reduced by 79 %, the water consumption is 96 % lower, and 66 % of the material costs are saved.

Find related publications in this database (Keywords)
Ultrafiltration
Scale-up
Dialysis
Cross-flow filtration
Ferrihydrite
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