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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Thompson, GR; Jenks, JD; Baddley, JW; Lewis, JS; Egger, M; Schwartz, IS; Boyer, J; Patterson, TF; Chen, SC; Pappas, PG; Hoenigl, M.
Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management.
Clin Microbiol Rev. 2023; 36(3):e0001923 Doi: 10.1128/cmr.00019-23 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Führende Autor*innen der Med Uni Graz
Hönigl Martin
Co-Autor*innen der Med Uni Graz
Boyer Johannes
Egger Matthias Florian
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Abstract:
Fungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by Aspergillus and Histoplasma spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use. The signs and symptoms of fungal endocarditis are nonspecific, and a high degree of clinical suspicion coupled with the judicious use of diagnostic tests is required for diagnosis. In addition to microbiological diagnostics (e.g., blood culture for Candida spp. or galactomannan testing and PCR for Aspergillus spp.), echocardiography remains critical for evaluation of potential infective endocarditis, although radionuclide imaging modalities such as 18F-fluorodeoxyglucose positron emission tomography/computed tomography are increasingly being used. A multimodal treatment approach is necessary: surgery is usually required and should be accompanied by long-term systemic antifungal therapy, such as echinocandin therapy for Candida endocarditis or voriconazole therapy for Aspergillus endocarditis.
Find related publications in this database (using NLM MeSH Indexing)
Humans - administration & dosage
Mycoses - drug therapy
Endocarditis - diagnosis, epidemiology, therapy
Endocarditis, Bacterial - diagnosis
Antifungal Agents - therapeutic use
Candidiasis - diagnosis
Candida - administration & dosage
Aspergillus - administration & dosage

Find related publications in this database (Keywords)
cardiac
diagnosis
endocarditis
endocardium
fungal
mycologic
mycology
treatment
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