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SHR Neuro Cancer Cardio Lipid Metab Microb
Reintar, S; Pochhacker, M; Obermayer, A; Eberhard, K; Zirlik, A; Verheyen, N; von Lewinski, D; Scherr, D; Hutz, B; Haudum, CW; Pieber, TR; Sourij, H; Obermayer-Pietsch, B.
Urinary C-Peptide to Creatinine Ratio (UCPCR) as Indicator for Metabolic Risk in Apparently Healthy Adults-A BioPersMed Cohort Study
NUTRIENTS. 2023; 15(9): 2073
Doi: 10.3390/nu15092073
Web of Science
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Obermayer-Pietsch Barbara
- Reintar Sharmaine
- Co-authors Med Uni Graz
- Eberhard Katharina
- Haudum Christoph
- Hutz Barbara
- Pieber Thomas
- Ramirez-Obermayer Anna Maria Antonia
- Scherr Daniel
- Sourij Harald
- Verheyen Nicolas Dominik
- von Lewinski Dirk
- Zirlik Andreas
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- Dimensions Citations:
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- Abstract:
- Background: C-peptide is produced in equimolar amounts with insulin frompancreatic beta cells, and thus is a fundamental biomarker for beta cell function. A non-invasive urinary C-peptide-to-creatinine ratio (UCPCR) has attracted attention as a biomarker formetabolic conditions. However, the UCPCR as an indicative risk predictor for prediabetes is still being investigated. Methods: We aimed to characterize UCPCRs in healthy people using American Diabetes Association (ADA) criteria and to evaluate theirmetabolic outcomes over time. A total of 1022 participants of the Biomarkers in Personalized Medicine cohort (BioPersMed) were screened for this study. Totals of 317 healthy with normal glucose metabolism, 87 prediabetic, and 43 diabetic subjects were included. Results: Prediabetic participants had a significantly higher UCPCR median value than healthy participants (p < 0.05). Dysglycaemia of healthy baseline participants was measured twice over 4.5 +/- 0.9 years; 25% and 30% were detected with prediabetes during follow-ups, predicted by UCPCR both for the first (p < 0.05) and the second visit (p < 0.05), respectively. This is in good agreementwith the negative predictiveUCPCR value of 60.2% based on logistic regression. UCPCR levelswere equal in both sexes. Conclusion: UCPCRmeasurements provide an indicative approach formetabolic risk, representing a potential use for prevention andmonitoring of impaired glucosemetabolism.
- Find related publications in this database (Keywords)
- UCPCR
- urinary C-peptide creatinine ratio
- BioPersMed cohort
- metabolic risk
- prediabetes