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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Griesbacher, T; Rainer, I; Heinemann, A; Groisman, D.
Haemodynamic and exocrine effects of caerulein at submaximal and supramaximal levels on the rat pancreas: role of cholecystokinin receptor subtypes.
Pancreatology. 2006; 6(1-2):65-75
Doi: 10.1159/000090025
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Griesbacher Thomas
- Co-Autor*innen der Med Uni Graz
- Heinemann Akos
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- Abstract:
- BACKGROUND: We have investigated the involvement of cholecystokinin (CCK) receptor subtypes in haemodynamic changes in the pancreas of anaesthetized rats during submaximal and supramaximal stimulation with the CCK analogue, caerulein. METHODS: For submaximal stimulation, caerulein (0.4 nmol/kg/h) was infused intravenously, while acute pancreatitis was induced by intraperitoneal injections of high doses of caerulein (3 x 25 nmol/kg). Pancreatic blood flow was measured by hydrogen clearance. RESULTS: Low caerulein doses increased pancreatic blood flow by 26 +/- 8% and vascular conductance by 24 +/- 4%. This effect was mimicked by the CCK2 agonist gastrin-17. All effects were abolished by a CCK2 antagonist while a CCK1 antagonist remained inactive. Conversely, amylase output by caerulein was abolished by CCK1 receptor blockade, but not by inhibition of CCK2 receptors. During caerulein-induced pancreatitis, vascular conductance increased by 109 +/- 26% and remained elevated throughout the experiment; vascular flow initially increased by 62 +/- 27% and then returned to baseline. The vascular effects were prevented by a CCK2 receptor antagonist, while the induction of pancreatitis was due to CCK1 receptor stimulation. CONCLUSIONS: Caerulein increases pancreatic vascular flow via activation of CCK2 receptors. This effect occurs both at submaximal and at supramaximal levels of exocrine stimulation.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Caerulein - pharmacology
- Female - pharmacology
- Gastrins - pharmacology
- Indoles - pharmacology
- Pancreas, Exocrine - blood supply
- Pancreatitis - chemically induced
- Rats - chemically induced
- Rats, Sprague-Dawley - chemically induced
- Receptor, Bradykinin B2 - antagonists and inhibitors
- Receptor, Cholecystokinin A - agonists
- Receptor, Cholecystokinin B - agonists
- Receptors, Cholecystokinin - drug effects
- Regional Blood Flow - drug effects
- Stimulation, Chemical - drug effects
- Find related publications in this database (Keywords)
- blood flow
- caerulein
- cholecystokinin receptors
- haemodynamics
- vascular conductance