Medizinische Universität Graz - Research portal
Navigation/Search
- Researchers
- Institutions
- Projects
- Publications
- Partners
- Sponsors
- Equipment
- Knowhow
- Fields of Research
"Faces" of the day:
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Chen, CY; Tien, CH; Chen, YH; Garrido, D; Farzi, A; Herzog, H; Fan, HY; Chen, YC.
Effect of Sucralose Intake on Human and Mouse/Rat Gut Microbiota Composition: A Systematic Review and Meta-Analysis
FOOD REV INT. 2023;
Doi: 10.1080/87559129.2023.2212045
Web of Science
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Farzi Aitak
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- IntroductionSucralose is a popular nonnutritive sweetener. The association of sucralose with gut microbiota and its effect on body weight remains unclear; therefore, we examined the effect of sucralose on human and mouse/rat gut microbiota composition.MethodsWe conducted a systematic review and meta-analysis by including clinical trials on the effect of sucralose on human and mouse/rat gut microbiota composition.ResultsOf nine studies, two were human trials, and seven were mouse/rat trials. In humans, sucralose intake resulted in significantly higher relative abundance of Bacteroidetes than controls (mean change in relative abundance = 0.24, P < 0.001); however, the converse was observed in mice/rats (mean change in relative abundance = -11.02,P = 0.01). The relative abundance of Actinobacteria significantly increased in humans after sucralose intake (mean change in relative abundance = 0.30, P < 0.01), and the relative abundance of Verrucomicrobia significantly decreased in mice/rats after sucralose intake (mean change in relative abundance = -1.43, P = 0.04).ConclusionsSucralose reduced obesity in humans by reducing the Firmicutes/Bacteroidetes (F/B) ratio and increasing the relative abundance of Actinobacteria. However, sucralose induced obesity in mice/rats by reducing the F/B ratio. More randomized clinical trials and international cooperation in sharing original data are warranted in the future.
- Find related publications in this database (Keywords)
- Sweetener
- sucralose
- gut microbiome
- humans
- mice
- rats