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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Hatab, I; Kneihsl, M; Bisping, E; Rainer, PP; Fandler-Höfler, S; Eppinger, S; Haidegger, M; Berger, N; Mangge, H; Schmidt, R; Enzinger, C; Gattringer, T.
The value of clinical routine blood biomarkers in predicting long-term mortality after stroke.
Eur Stroke J. 2023; 8(2): 532-540.
Doi: 10.1177/23969873231162125
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Hatab Isra
- Kneihsl Markus
- Co-authors Med Uni Graz
- Berger Natalie
- Bisping Egbert Hubertus
- Enzinger Christian
- Eppinger Sebastian
- Fandler-Höfler Simon
- Gattringer Thomas
- Haidegger Melanie
- Mangge Harald
- Rainer Peter
- Schmidt Reinhold
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- Abstract:
- BACKGROUND: Several blood biomarkers have been identified as predictors for poor outcome after ischemic stroke. However, recent studies mainly focused on single or experimental biomarkers and considered rather short follow-up intervals limiting their value for daily clinical practice. We, therefore, aimed to compare various clinical routine blood biomarkers for their predictive value on post-stroke mortality over a 5-year follow-up period. PATIENTS AND METHODS: This data analysis of a prospective single-center study included all consecutive ischemic stroke patients admitted to the stroke unit of our university hospital over a 1-year period. Various blood biomarkers of inflammation, heart failure, metabolic disorders, and coagulation were analyzed from standardized routine blood samples collected within 24 h of hospital admission. All patients underwent a thorough diagnostic workup and were followed for 5 years post-stroke. RESULTS: Of 405 patients (mean age: 70.3 years), 72 deceased (17.8%) during the follow-up period. While various routine blood biomarkers were associated with post-stroke mortality in univariable analyses, only NT-proBNP remained an independent predictor (adjusted odds ratio 5.1; 95% CI 2.0-13.1; p < 0.001) for death after stroke. NT-proBNP levels ⩾794 pg/mL (n = 169, 42%) had a sensitivity of 90% for post-stroke mortality with a negative predictive value of 97% and was additionally associated with cardioembolic stroke and heart failure (each p ⩽ 0.05). CONCLUSION: NT-proBNP represents the most relevant routine blood-based biomarker for the prediction of long-term mortality after ischemic stroke. Increased NT-proBNP levels indicate a vulnerable subgroup of stroke patients in which early and thorough cardiovascular assessment and consistent follow-ups could improve outcome after stroke.
- Find related publications in this database (Keywords)
- Ischemic stroke
- post-stroke mortality
- blood biomarker
- NT-proBNP
- 5-year follow-up