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SHR Neuro Cancer Cardio Lipid Metab Microb
Dietrich, E; Jomard, A; Osto, E.
Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation.
Front Cardiovasc Med. 2022; 9: 989428
Doi: 10.3389/fcvm.2022.989428
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- Leading authors Med Uni Graz
- Osto Elena
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- Abstract:
- Atherosclerotic cardiovascular disease is the leading cause of death worldwide. Intense research in vascular biology has advanced our knowledge of molecular mechanisms of its onset and progression until complications; however, several aspects of the patho-physiology of atherosclerosis remain to be further elucidated. Endothelial cell homeostasis is fundamental to prevent atherosclerosis as the appearance of endothelial cell dysfunction is considered the first pro-atherosclerotic vascular modification. Physiologically, high density lipoproteins (HDLs) exert protective actions for vessels and in particular for ECs. Indeed, HDLs promote endothelial-dependent vasorelaxation, contribute to the regulation of vascular lipid metabolism, and have immune-modulatory, anti-inflammatory and anti-oxidative properties. Sex- and gender-dependent differences are increasingly recognized as important, although not fully elucidated, factors in cardiovascular health and disease patho-physiology. In this review, we highlight the importance of sex hormones and sex-specific gene expression in the regulation of HDL and EC cross-talk and their contribution to cardiovascular disease.
- Find related publications in this database (Keywords)
- HDL
- endothelial cells
- sex differences
- cardiovascular disease
- HDL-endothelial crosstalk