Medizinische Universität Graz - Research portal
Navigation/Search
- Researchers
- Institutions
- Projects
- Publications
- Partners
- Sponsors
- Equipment
- Knowhow
- Fields of Research
"Faces" of the day:
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Evans, PC; Rainger, GE; Mason, JC; Guzik, TJ; Osto, E; Stamataki, Z; Neil, D; Hoefer, IE; Fragiadaki, M; Waltenberger, J; Weber, C; Bochaton-Piallat, ML; Bäck, M.
Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science.
Cardiovasc Res. 2020; 116(14):2177-2184
Doi: 10.1093/cvr/cvaa230
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Osto Elena
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The COVID-19 pandemic is an unprecedented healthcare emergency causing mortality and illness across the world. Although primarily affecting the lungs, the SARS-CoV-2 virus also affects the cardiovascular system. In addition to cardiac effects, e.g. myocarditis, arrhythmias, and myocardial damage, the vasculature is affected in COVID-19, both directly by the SARS-CoV-2 virus, and indirectly as a result of a systemic inflammatory cytokine storm. This includes the role of the vascular endothelium in the recruitment of inflammatory leucocytes where they contribute to tissue damage and cytokine release, which are key drivers of acute respiratory distress syndrome (ARDS), in disseminated intravascular coagulation, and cardiovascular complications in COVID-19. There is also evidence linking endothelial cells (ECs) to SARS-CoV-2 infection including: (i) the expression and function of its receptor angiotensin-converting enzyme 2 (ACE2) in the vasculature; (ii) the prevalence of a Kawasaki disease-like syndrome (vasculitis) in COVID-19; and (iii) evidence of EC infection with SARS-CoV-2 in patients with fatal COVID-19. Here, the Working Group on Atherosclerosis and Vascular Biology together with the Council of Basic Cardiovascular Science of the European Society of Cardiology provide a Position Statement on the importance of the endothelium in the underlying pathophysiology behind the clinical presentation in COVID-19 and identify key questions for future research to address. We propose that endothelial biomarkers and tests of function (e.g. flow-mediated dilatation) should be evaluated for their usefulness in the risk stratification of COVID-19 patients. A better understanding of the effects of SARS-CoV-2 on endothelial biology in both the micro- and macrovasculature is required, and endothelial function testing should be considered in the follow-up of convalescent COVID-19 patients for early detection of long-term cardiovascular complications.
- Find related publications in this database (using NLM MeSH Indexing)
- Angiotensin-Converting Enzyme 2 - metabolism
- COVID-19 - metabolism, physiopathology, virology
- Cardiovascular Agents - therapeutic use
- Cardiovascular Diseases - drug therapy, metabolism, physiopathology, virology
- Cytokines - metabolism
- Endothelium, Vascular - drug effects, metabolism, physiopathology, virology
- Host-Pathogen Interactions - administration & dosage
- Humans - administration & dosage
- Inflammation Mediators - metabolism
- Prognosis - administration & dosage
- Risk Assessment - administration & dosage
- Risk Factors - administration & dosage
- SARS-CoV-2 - drug effects, metabolism, pathogenicity
- Virus Internalization - administration & dosage
- COVID-19 Drug Treatment - administration & dosage
- Find related publications in this database (Keywords)
- COVID-19
- SARS-CoV-2
- Endothelium