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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Haider, A; Possner, M; Messerli, M; Bengs, S; Osto, E; Maredziak, M; Portmann, A; Fiechter, M; Giannopoulos, AA; Treyer, V; Gaisl, T; von, Felten, E; Patriki, D; Benz, DC; Fuchs, TA; Gräni, C; Pazhenkottil, AP; Buechel, RR; Kaufmann, PA; Gebhard, C.
Quantification of intrathoracic fat adds prognostic value in women undergoing myocardial perfusion imaging.
Int J Cardiol. 2019; 292:258-264 Doi: 10.1016/j.ijcard.2019.04.092
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Co-Autor*innen der Med Uni Graz
Osto Elena
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Abstract:
AIM: Amongst patients with coronary artery disease (CAD), women experience relatively worse outcomes as compared to men. Evidence to date has failed to explore unique female imaging targets as major determinants of cardiovascular risk. We sought to assess the prognostic value of epicardial (EFV) and intrathoracic fat volume (IFV) quantification in women and men with suspected and known CAD. METHODS AND RESULTS: Intrathoracic fat volume and EFV were calculated from non-contrast CT and analyzed in a propensity-matched cohort of 190 patients (95 women, mean age 62.5 ± 11.3 years) undergoing myocardial perfusion imaging (MPI) and coronary computed tomography angiography (CCTA) for evaluation of CAD. IFV and EFV were significantly lower in women as compared to men (198.2 ± 78.4 vs 293.2 ± 114.7 cm3 and 105.6 ± 48.9 vs 135.8 ± 60.9 cm3, p < 0.001) and showed a strong association with coronary artery calcium score (CACS) and obstructive CAD in women (p < 0.05), but not in men. Fat volumes were not related to abnormal MPI in either population (p = NS). During a median follow-up of 2.8 years, high IFV was associated with reduced event free survival (log rank = 0.019 vs low IFV) in women, but not in men. Accordingly, a multivariate Cox regression model adjusted for cardiovascular risk factors, CACS, CCTA, and MPI findings selected IFV as a significant predictor of major adverse cardiovascular events (MACE) in women (HR 1.32, 95%CI 1.18-1.55, p = 0.001). CONCLUSION: Quantification of IFV provides incremental prognostic value for MACE in women, beyond that provided by traditional risk factors and imaging findings.
Find related publications in this database (using NLM MeSH Indexing)
Adipose Tissue - diagnostic imaging, metabolism
Aged - administration & dosage
Body Fat Distribution - methods
Cohort Studies - administration & dosage
Computed Tomography Angiography - methods
Coronary Artery Disease - diagnostic imaging, metabolism
Female - administration & dosage
Follow-Up Studies - administration & dosage
Humans - administration & dosage
Male - administration & dosage
Middle Aged - administration & dosage
Myocardial Perfusion Imaging - methods
Pericardium - diagnostic imaging, metabolism
Prognosis - administration & dosage
Single Photon Emission Computed Tomography Computed Tomography - methods
Thoracic Cavity - diagnostic imaging, metabolism

Find related publications in this database (Keywords)
Intrathoracic fat volume
Epicardial fat volume
Myocardial perfusion imaging
Coronary computed tomography angiography
Women
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