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Joshi, AA; Vocanson, M; Nicolas, JF; Wolf, P; Patra, V.
Microbial derived antimicrobial peptides as potential therapeutics in atopic dermatitis.
Front Immunol. 2023; 14: 1125635 Doi: 10.3389/fimmu.2023.1125635 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Führende Autor*innen der Med Uni Graz
Joshi Aaroh Anand
Patra Vijaykumar
Co-Autor*innen der Med Uni Graz
Wolf Peter
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Abstract:
Atopic dermatitis (AD) is a common chronic inflammatory skin disease that significantly affects the patient's quality of life. A disrupted skin barrier, type 2 cytokine-dominated inflammation, and microbial dysbiosis with increased Staphylococcus aureus colonization are critical components of AD pathogenesis. Patients with AD exhibit decreased expression of antimicrobial peptides (AMPs) which is linked to increased colonization by Staphylococcus aureus. The skin microbiome itself is a source of several AMPs. These host- and microbiome-derived AMPs define the microbial landscape of the skin based on their differential antimicrobial activity against a range of skin microbes or their quorum sensing inhibitory properties. These are particularly important in preventing and limiting dysbiotic colonization with Staphylococcus aureus. In addition, AMPs are critical for immune homeostasis. In this article, we share our perspectives about the implications of microbial derived AMPs in AD patients and their potential effects on overlapping factors involved in AD. We argue and discuss the potential of bacterial AMPs as therapeutics in AD.

Find related publications in this database (Keywords)
antimicrobial peptides
atopic dermatitis
autoinducing peptides
bacteriocins
skin microbiome
Staphylococcus aureus
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