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Wicaksono, WA; Reisenhofer-Graber, T; Erschen, S; Kusstatscher, P; Berg, C; Krause, R; Cernava, T; Berg, G.
Phyllosphere-associated microbiota in built environment: Do they have the potential to antagonize human pathogens?
J ADV RES. 2023; 43: 109-121. Doi: 10.1016/j.jare.2022.02.003 [OPEN ACCESS]
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Co-authors Med Uni Graz
Erschen Sabine
Krause Robert
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Abstract:
Introduction: The plant microbiota is known to protect its host against invasion by plant pathogens. Recent studies have indicated that the microbiota of indoor plants is transmitted to the local built envi-ronment where it might fulfill yet unexplored functions. A better understanding of the interplay of such microbial communities with human pathogens might provide novel cues related to natural inhibition of them. Objective: We studied the plant microbiota of two model indoor plants, Musa acuminata and Chlorophytum comosum, and their effect on human pathogens. The main objective was to identify mech-anisms by which the microbiota of indoor plants inhibits human-pathogenic bacteria. Methods: Microbial communities and functioning were investigated using a comprehensive set of exper-iments and methods combining amplicon and shotgun metagenomic analyses with results from interac-tion assays. Results: A diverse microbial community was found to be present on Musa and Chlorophytum grown in dif-ferent indoor environments; the datasets comprised 1066 bacterial, 1261 fungal, and 358 archaeal ASVs. Bacterial communities were specific for each plant species, whereas fungal and archaeal communities were primarily shaped by the built environment. Sphingomonas and Bacillus were found to be prevalent components of a ubiquitous core microbiome in the two model plants; they are well-known for antago-nistic activity towards plant pathogens. Interaction assays indicated that they can also antagonize oppor-tunistic human pathogens. Moreover, the native plant microbiomes harbored a broad spectrum of biosynthetic gene clusters, and in parallel, a variety of antimicrobial resistance genes. By conducting com-parative metagenomic analyses between plants and abiotic surfaces, we found that the phyllosphere microbiota harbors features that are clearly distinguishable from the surrounding abiotic surfaces. Conclusions: Naturally occurring phyllosphere bacteria can potentially act as a protective shield against opportunistic human pathogens. This knowledge and the underlying mechanisms can provide an impor-tant basis to establish a healthy microbiome in built environments. (c) 2022 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Find related publications in this database (Keywords)
Human health
Indoor plant microbiome
Indoor microbiome
Built environment
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