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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Moser, O; Müller, A; Aberer, F; Aziz, F; Kojzar, H; Sourij, C; Obermayer, A; Abbas, F; Birnbaumer, P; Lenz, J; Mursic, I; Sternad, C; Hönger, L; Ziko, H; Pferschy, PN; Tripolt, N; Sourij, H.
Comparison of Insulin Glargine 300 U/mL and Insulin Degludec 100 U/mL Around Spontaneous Exercise Sessions in Adults with Type 1 Diabetes: A Randomized Cross-Over Trial (ULTRAFLEXI-1 Study).
Diabetes Technol Ther. 2023; 25(3):161-168
Doi: 10.1089/dia.2022.0422
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Moser Othmar
- Sourij Harald
- Co-authors Med Uni Graz
- Abbas Farah
- Aberer Felix
- Aziz Faisal
- Kojzar Harald
- Lenz Jacqueline
- Müller Alexander
- Mursic Ines
- Pferschy Peter
- Ramirez-Obermayer Anna Maria Antonia
- Sourij Caren
- Sternad Christoph Peter
- Tripolt Norbert
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- Abstract:
- Aims: In the ULTRAFLEXI-1 study, we compared basal insulin Glargine 300 U/mL (IGlar U300) and insulin Degludec 100 U/mL (IDeg U100) for time below range <70 mg/dL (TBR<70; 3.9 mmol/L) in two different doses (100% and 75% of the regular dose) when used around spontaneous exercise sessions in adults with type 1 diabetes. Methods: A randomized, single-center, four-period, cross-over trial was performed and in each of the four 2-weeks-periods, participants attended six spontaneous 60 min moderate-intensity evening cycle ergometer exercise sessions. The basal insulin administered on the exercise days were IGlar U300 100% or 75% of the regular dose or IDeg U100 100% or 75%, respectively (morning injection). The primary outcome was the TBR<70 during the 24 h postexercise periods of the six spontaneous exercise sessions in the four trial arms and was analyzed in hierarchical order using the repeated measures linear mixed model. Results: Twenty-five people with type 1 diabetes were enrolled (14 males) with a mean age of 41.4 ± 11.9 years and an HbA1c of 7.5% ± 0.8% (59 ± 9 mmol/mol). The mean ± standard error of mean TBR<70 during the 24 h periods following the exercise sessions was 2.71% ± 0.51% for IGlar U300 (100%) and 4.37% ± 0.69% for IDeg U100 (100%) (P = 0.023) as well as 2.28% ± 0.53% for IGlar U300 and 2.55% ± 0.58% for IDeg U100 when using a 75% dose on exercise days (P = 0.720). Time in glucose range70-180 was the highest in the IDeg U100 (100%) group. Conclusions: TBR<70 within the first 24 h after spontaneous exercise sessions was significantly lower when receiving IGlar U300 compared to IDeg U100 when a regular basal dose was administered.
- Find related publications in this database (using NLM MeSH Indexing)
- Male - administration & dosage
- Adult - administration & dosage
- Humans - administration & dosage
- Middle Aged - administration & dosage
- Insulin Glargine - administration & dosage
- Diabetes Mellitus, Type 1 - administration & dosage
- Hypoglycemic Agents - administration & dosage
- Cross-Over Studies - administration & dosage
- Blood Glucose - administration & dosage
- Find related publications in this database (Keywords)
- CGM
- Time in range
- Time below range
- Exercise
- Type 1 diabetes
- 2nd generation basal insulin