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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Mooslechner, AA; Schuller, M; Artinger, K; Kirsch, AH; Schabhüttl, C; Eller, P; Rosenkranz, AR; Eller, K.
Low-Dose rIL-15 Protects from Nephrotoxic Serum Nephritis via CD8+ T Cells.
Cells. 2022; 11(22):
Doi: 10.3390/cells11223656
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Eller Kathrin
- Mooslechner Agnes Anna
- Co-authors Med Uni Graz
- Artinger Katharina
- Eller Philipp
- Kirsch Alexander
- Rosenkranz Alexander
- Schabhüttl Corinna
- Schuller Max
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- Abstract:
- Rapid progressive glomerulonephritis (GN) often leads to end-stage kidney disease, driving the need for renal replacement therapy and posing a global health burden. Low-dose cytokine-based immunotherapies provide a new strategy to treat GN. IL-15 is a strong candidate for the therapy of immune-mediated kidney disease since it has proven to be tubular-protective before. Therefore, we set out to test the potential of low-dose rIL-15 treatment in a mouse model of nephrotoxic serum nephritis (NTS), mimicking immune complex-driven GN in humans. A single low-dose treatment with rIL-15 ameliorated NTS, reflected by reduced albuminuria, less tissue scarring, fewer myeloid cells in the kidney, and improved tubular epithelial cell survival. In addition, CD8+ T cells, a primary target of IL-15, showed altered gene expression and function corresponding with less cytotoxicity mediated by rIL-15. With the use of transgenic knock-out mice, antibody depletion, and adoptive cell transfer studies, we here show that the beneficial effects of rIL-15 treatment in NTS depended on CD8+ T cells, suggesting a pivotal role for them in the underlying mechanism. Our findings add to existing evidence of the association of IL-15 with kidney health and imply a potential for low-dose rIL-15 immunotherapies in GN.
- Find related publications in this database (Keywords)
- glomerulonephritis
- interleukin-15
- renal tubular epithelial cell