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SHR Neuro Cancer Cardio Lipid Metab Microb

Hoegenauer, C; Hammer, HF; Mahnert, A; Moissl-Eichinger, C.
Methanogenic archaea in the human gastrointestinal tract.
Nat Rev Gastroenterol Hepatol. 2022; 19(12):805-813 Doi: 10.1038/s41575-022-00673-z
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Leading authors Med Uni Graz
Hoegenauer Christoph
Moissl-Eichinger Christine
Co-authors Med Uni Graz
Hammer Heinz
Mahnert Alexander
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Abstract:
The human microbiome is strongly interwoven with human health and disease. Besides bacteria, viruses and eukaryotes, numerous archaea are located in the human gastrointestinal tract and are responsible for methane production, which can be measured in clinical methane breath analyses. Methane is an important readout for various diseases, including intestinal methanogen overgrowth. Notably, the archaea responsible for methane production are largely overlooked in human microbiome studies due to their non-bacterial biology and resulting detection issues. As such, their importance for health and disease remains largely unclear to date, in particular as not a single archaeal representative has been deemed to be pathogenic. In this Perspective, we discuss the current knowledge on the clinical relevance of methanogenic archaea. We explain the archaeal unique response to antibiotics and their negative and positive effects on human physiology, and present the current understanding of the use of methane as a diagnostic marker.
Find related publications in this database (using NLM MeSH Indexing)
Humans - administration & dosage
Archaea - physiology
Euryarchaeota - administration & dosage
Gastrointestinal Tract - microbiology
Methane - administration & dosage
Bacteria - administration & dosage

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