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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Streese, L; Habisch, H; Deiseroth, A; Carrard, J; Infanger, D; Schmidt-Trucksäss, A; Madl, T; Hanssen, H.
Lipoprotein Subclasses Independently Contribute to Subclinical Variance of Microvascular and Macrovascular Health.
MOLECULES. 2022; 27(15): Doi: 10.3390/molecules27154760 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Führende Autor*innen der Med Uni Graz
Habisch Hansjörg
Madl Tobias
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Abstract:
Lipoproteins are important cardiovascular (CV) risk biomarkers. This study aimed to investigate the associations of lipoprotein subclasses with micro- and macrovascular biomarkers to better understand how these subclasses relate to atherosclerotic CV diseases. One hundred and fifty-eight serum samples from the EXAMIN AGE study, consisting of healthy individuals and CV risk patients, were analysed with nuclear magnetic resonance (NMR) spectroscopy to quantify lipoprotein subclasses. Microvascular health was quantified by measuring retinal arteriolar and venular diameters. Macrovascular health was quantified by measuring carotid-to-femoral pulse wave velocity (PWV). Nineteen lipoprotein subclasses showed statistically significant associations with retinal vessel diameters and nine with PWV. These lipoprotein subclasses together explained up to 26% of variation (R2 = 0.26, F(29,121) = 2.80, p < 0.001) in micro- and 12% (R2 = 0.12, F(29,124) = 1.70, p = 0.025) of variation in macrovascular health. High-density (HDL-C) and low-density lipoprotein cholesterol (LDL-C) as well as triglycerides together explained up to 13% (R2 = 0.13, F(3143) = 8.42, p < 0.001) of micro- and 8% (R2 = 0.08, F(3145) = 5.46, p = 0.001) of macrovascular variation. Lipoprotein subclasses seem to reflect micro- and macrovascular end organ damage more precisely as compared to only measuring HDL-C, LDL-C and triglycerides. Further studies are needed to analyse how the additional quantification of lipoprotein subclasses can improve CV risk stratification and CV disease prediction.
Find related publications in this database (using NLM MeSH Indexing)
Biomarkers - administration & dosage
Cholesterol, LDL - administration & dosage
Humans - administration & dosage
Lipoproteins - administration & dosage
Lipoproteins, LDL - administration & dosage
Pulse Wave Analysis - administration & dosage
Triglycerides - administration & dosage

Find related publications in this database (Keywords)
cardiovascular risk
lipids
NMR spectroscopy
pulse wave velocity
retinal vessel diameters
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