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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Klobučar, I; Degoricija, V; Potočnjak, I; Trbušić, M; Pregartner, G; Berghold, A; Fritz-Petrin, E; Habisch, H; Madl, T; Frank, S.
HDL-apoA-II Is Strongly Associated with 1-Year Mortality in Acute Heart Failure Patients.
BIOMEDICINES. 2022; 10(7): Doi: 10.3390/biomedicines10071668 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Führende Autor*innen der Med Uni Graz
Frank Sasa
Co-Autor*innen der Med Uni Graz
Berghold Andrea
Fritz-Petrin Eva Verena
Habisch Hansjörg
Madl Tobias
Pregartner Gudrun
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Abstract:
The prognostic value of the subset of high-density lipoprotein (HDL) particles containing apolipoprotein (apo)A-II (HDL-apoA-II) in acute heart failure (AHF) remains unexplored. In this study, baseline serum levels of HDL-apoA-II (total and subfractions 1-4) were measured in 315 AHF patients using NMR spectroscopy. The mean patient age was 74.2 ± 10.5 years, 136 (43.2%) were female, 288 (91.4%) had a history of cardiomyopathy, 298 (94.6%) presented as New York Heart Association class 4, and 118 (37.5%) patients died within 1 year after hospitalization for AHF. Multivariable Cox regression analyses, adjusted for age and sex as well as other clinical and laboratory parameters associated with 1-year mortality in the univariable analyses, revealed a significant inverse association of HDL-apoA-II (hazard ratio (HR) 0.67 per 1 standard deviation (1 SD) increase, 95% confidence interval (CI) 0.47-0.94, p = 0.020), HDL2-apoA-II (HR 0.72 per 1 SD increase, 95% CI 0.54-0.95, p = 0.019), and HDL3-apoA-II (HR 0.59 per 1 SD increase, 95% CI 0.43-0.80, p < 0.001) with 1-year mortality. We conclude that low baseline HDL-apoA-II, HDL2-apoA-II, and HDL3-apoA-II serum levels are associated with increased 1-year mortality in AHF patients and may thus be of prognostic value in AHF.

Find related publications in this database (Keywords)
acute heart failure
high-density lipoprotein
apoA-II
HDL-p
mortality
NMR spectroscopy
prognostic biomarkers
risk
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