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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Lackner, S; Sconocchia, T; Ziegler, T; Passegger, C; Meier-Allard, N; Schwarzenberger, E; Wonisch, W; Lahousen, T; Kohlhammer-Dohr, A; Mörkl, S; Derler, M; Strobl, H; Holasek, SJ.
Immunomodulatory Effects of Aronia Juice Polyphenols-Results of a Randomized Placebo-Controlled Human Intervention Study and Cell Culture Experiments.
Antioxidants (Basel). 2022; 11(7): Doi: 10.3390/antiox11071283 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Holasek Sandra Johanna
Lackner Sonja
Co-Autor*innen der Med Uni Graz
Kohlhammer-Dohr Alexandra
Lahousen-Luxenberger Theresa
Leal Garcia Sabrina
Meier-Allard Nathalie
Passegger Christina Angelika
Schwarzenberger Elke
Sconocchia Tommaso
Strobl Herbert
Wonisch Willibald
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Abstract:
Dietary polyphenols, which are present in Aronia melanocarpa, have been associated with various beneficial effects on human health including antioxidant, antiviral, and anti-inflammatory activities. We aimed to investigate the immunomodulatory effects of aronia juice polyphenols in a randomized placebo-controlled human intervention study and cell culture experiments. A total of 40 females were asked to consume either 200 mL of aronia juice or a placebo drink for six weeks and were investigated again after a washout period of another six weeks. We observed that only half of the participants tolerated the aronia juice well (Vt) and the other half reported complaints (Vc). The placebo (P) was generally tolerated with one exception (p = 0.003). Plasma polyphenol levels increased significantly in Vt after the intervention (p = 0.024) but did neither in P nor in Vc. Regulatory T cell (Treg) frequencies remained constant in Vt and P during the intervention, whereas Tregs decreased in Vc (p = 0.018). In cell culture, inhibiting effects of ferulic acid (p = 0.0005) and catechin (p = 0.0393) on the differentiation of Tregs were observed as well as reduced activation of CD4-T cells in ferulic acid (p = 0.0072) and aronia juice (p = 0.0163) treated cells. Interestingly, a CD4+CD25-FoxP3+ cell population emerged in vitro in response to aronia juice, but not when testing individual polyphenols. In conclusion, our data strengthen possible individual hormetic effects, the importance of the food matrix for bioactivity, and the need for further investigations on possible impacts of specific physiological features such as the gut microbiota in the context of personalized nutrition.

Find related publications in this database (Keywords)
Aronia melanocarpa juice
polyphenols
regulatory T cells
tolerability
oxidative stress
bioavailability
hormesis
immunomodulation
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