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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Korten, I; Oestreich, MA; Frey, U; Moeller, A; Jung, A; Spinas, R; Mueller-Suter, D; Trachsel, D; Rochat, I; Spycher, B; Latzin, P; Casaulta, C; Ramsey, K, , SCILD, and, BILD, study, group.
Respiratory symptoms do not reflect functional impairment in early CF lung disease.
J Cyst Fibros. 2021; 20(6):957-964 Doi: 10.1016/j.jcf.2021.04.006
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Abstract:
BACKGROUND: Lung disease can develop within the first year of life in infants with cystic fibrosis (CF). However, the frequency and severity of respiratory symptoms in infancy are not known. METHODS: We assessed respiratory symptoms in 50 infants with CF and 50 healthy matched controls from two prospective birth cohort studies. Respiratory symptoms and respiratory rate were documented by standardized weekly interviews throughout the first year. Infants performed multiple breath washout in the first weeks of life. RESULTS: We analyzed 4552 data points (2217 in CF). Respiratory symptoms (either mild or severe) were not more frequent in infants with CF (OR:1.1;95% CI:[0.76, 1.59]; p=0.6). Higher lung clearance index and higher respiratory rate in infants with CF were not associated with respiratory symptoms. CONCLUSIONS: We found no difference in respiratory symptoms between healthy and CF infants. These data indicate that early CF lung disease may not be captured by clinical presentation alone.
Find related publications in this database (using NLM MeSH Indexing)
Case-Control Studies - administration & dosage
Cystic Fibrosis - physiopathology
Female - administration & dosage
Humans - administration & dosage
Infant - administration & dosage
Male - administration & dosage
Predictive Value of Tests - administration & dosage
Prospective Studies - administration & dosage
Respiratory Function Tests - administration & dosage
Respiratory Rate - administration & dosage

Find related publications in this database (Keywords)
Cystic fibrosis
Infancy
Respiratory symptoms
Cohort study
Healthy controls
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