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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Patra, V; Strobl, J; Atzmüller, D; Reininger, B; Kleissl, L; Gruber-Wackernagel, A; Nicolas, JF; Stary, G; Vocanson, M; Wolf, P.
Accumulation of Cytotoxic Skin Resident Memory T Cells and Increased Expression of IL-15 in Lesional Skin of Polymorphic Light Eruption.
Front Med (Lausanne). 2022; 9: 908047
Doi: 10.3389/fmed.2022.908047
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- Führende Autor*innen der Med Uni Graz
- Patra Vijaykumar
- Wolf Peter
- Co-Autor*innen der Med Uni Graz
- Gruber-Wackernagel Alexandra
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- Abstract:
- Patients with polymorphic light eruption (PLE) develop lesions upon the first exposure to sun in spring/summer, but lesions usually subside during season due to the natural (or medical) photohardening. However, these lesions tend to reappear the following year and continue to do so in most patients, suggesting the presence of a disease memory. To study the potential role of skin resident memory T cells (Trm), we investigated the functional phenotype of Trm and the expression of IL-15 in PLE. IL-15 is known to drive Trm proliferation and survival. Multiplex immunofluorescence was used to quantify the expression of CD3, CD4, CD8, CD69, CD103, CD49a, CD11b, CD11c, CD68, granzyme B (GzmB), interferon-gamma (IFN-γ), and IL-15 in formalin-fixed, paraffin-embedded lesional skin samples from PLE patients and healthy skin from control subjects. Unlike the constitutive T cell population in healthy skin, a massive infiltration of T cells in the dermis and epidermis was observed in PLE, and the majority of these belonged to CD8+ T cells which express Trm markers (CD69, CD103, CD49a) and produced cytotoxic effector molecules GzmB and IFN-γ. Higher numbers of CD3+ T cells and CD11b+CD68+ macrophages produced IL-15 in the dermis as compared to healthy skin. The dominant accumulation of cytotoxic Trm cells and increased expression of IL-15 in lesional skin of PLE patients strongly indicates the potential role of skin Trm cells in the disease manifestation and recurrence.
- Find related publications in this database (Keywords)
- sun allergy
- polymorphic light eruption
- disease recurrence
- inflammation
- disease memory
- resident memory T cell (TrM)