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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Krstic, J; Deutsch, A; Fuchs, J; Gauster, M; Gorsek, Sparovec, T; Hiden, U; Krappinger, JC; Moser, G; Pansy, K; Szmyra, M; Gold, D; Feichtinger, J; Huppertz, B.
(Dis)similarities between the Decidual and Tumor Microenvironment.
Biomedicines. 2022; 10(5):
Doi: 10.3390/biomedicines10051065
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Deutsch Alexander
- Feichtinger Julia
- Krstic Jelena
- Co-authors Med Uni Graz
- Fuchs Julia
- Gauster Martin
- Gold ehem Ulrich Daniela
- Gorsek Sparovec Tina
- Hiden Ursula
- Huppertz Berthold
- Krappinger Julian Christopher
- Moser Gerit
- Pansy Katrin
- Szmyra-Polomka Marta Malwina
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- Abstract:
- Placenta-specific trophoblast and tumor cells exhibit many common characteristics. Trophoblast cells invade maternal tissues while being tolerated by the maternal immune system. Similarly, tumor cells can invade surrounding tissues and escape the immune system. Importantly, both trophoblast and tumor cells are supported by an abetting microenvironment, which influences invasion, angiogenesis, and immune tolerance/evasion, among others. However, in contrast to tumor cells, the metabolic, proliferative, migrative, and invasive states of trophoblast cells are under tight regulatory control. In this review, we provide an overview of similarities and dissimilarities in regulatory processes that drive trophoblast and tumor cell fate, particularly focusing on the role of the abetting microenvironments.
- Find related publications in this database (Keywords)
- decidual microenvironment
- tumor microenvironment
- placenta
- immune cells
- proliferation
- invasion
- tumor cell
- trophoblast