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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zimmermann, P; Aberer, F; Braun, M; Sourij, H; Moser, O.
The Arrhythmogenic Face of COVID-19: Brugada ECG Pattern in SARS-CoV-2 Infection.
J CARDIOVASC DEV DIS. 2022; 9(4):
Doi: 10.3390/jcdd9040096
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- Führende Autor*innen der Med Uni Graz
- Aberer Felix
- Co-Autor*innen der Med Uni Graz
- Moser Othmar
- Sourij Harald
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- Abstract:
- In 1992, Brugada syndrome (BS) was first described; an often unrecognized cardiac conduction disorder mainly associated with unexplained sudden cardiac arrest and consecutive syncope. Nevertheless, the pathomechanism of BS and sudden cardiac death remains mainly explained. Mutations in the cardiac sodium channels, which cause a reduction or functional loss of these channels, are associated with characteristic electrocardiographic (ECG) abnormalities and malignant arrhythmia. The majority of affected people are previously healthy and unaware of their genetic predisposition for BS and might experience ventricular tachyarrhythmias and cardiac arrest potentially triggered by several factors (e.g., alcohol, sodium channel blockers, psychotropic drugs, and fever). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was firstly identified in Wuhan in early December 2019 and rapidly spread worldwide as coronavirus disease (COVID-19). COVID-19 is typically characterized by a severe inflammatory response, activation of the immune system, and high febrile illness. Due to this condition, symptomatic COVID-19 infection or vaccination might serve as inciting factor for unmasking the Brugada pattern and represents a risk factor for developing proarrhythmic complications. The aim of this narrative review was to detail the association between virus-related issues such as fever, electrolyte disturbance, and inflammatory stress of COVID-19 infection with transient Brugada-like symptoms and ECG-pattern and its susceptibility to proarrhythmogenic episodes.
- Find related publications in this database (Keywords)
- Brugada syndrome
- Brugada ECG pattern
- SARS-CoV-2
- COVID-19
- pandemic