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SHR Neuro Cancer Cardio Lipid Metab Microb
Röhling, M; Kempf, K; Banzer, W; Braumann, KM; Führer-Sakel, D; Halle, M; McCarthy, D; Martin, S; Scholze, J; Toplak, H; Berg, A; Predel, HG; Acoorh, Study, Group.
A High-Protein and Low-Glycemic Formula Diet Improves Blood Pressure and Other Hemodynamic Parameters in High-Risk Individuals.
NUTRIENTS. 2022; 14(7):
Doi: 10.3390/nu14071443
[OPEN ACCESS]
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- Co-authors Med Uni Graz
- Toplak Hermann
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- Abstract:
- Low-caloric formula diets can improve hemodynamic parameters of patients with type 2 diabetes. We, therefore, hypothesized that persons with overweight or obesity can benefit from a high-protein, low-glycemic but moderate-caloric formula diet. This post-hoc analysis of the Almased Concept against Overweight and Obesity and Related Health Risk- (ACOORH) trial investigated the impact of a lifestyle intervention combined with a formula diet (INT, n = 308) compared to a control group with lifestyle intervention alone (CON, n = 155) on hemodynamic parameters (systolic and diastolic blood pressure (SBP, DBP), resting heart rate (HR), and pulse wave velocity (PWV)) in high-risk individuals with prehypertension or hypertension. INT replaced meals during the first 6 months (1 week: 3 meals/day; 2-4 weeks: 2 meals/day; 5-26 weeks: 1 meal/day). Study duration was 12 months. From the starting cohort, 304 (68.3%, INT: n = 216; CON: n = 101) participants had a complete dataset. Compared to CON, INT significantly reduced more SBP (-7.3 mmHg 95% CI [-9.2; -5.3] vs. -3.3 mmHg [-5.9; -0.8], p < 0.049) and DBP (-3.7 mmHg [-4.9; -2.5] vs. -1.4 mmHg [-3.1; 0.2], p < 0.028) after 12 months. Compared to CON, INT showed a pronounced reduction in resting HR and PWV after 6 months but both lost significance after 12 months. Changes in SBP, DBP, and PWV were significantly associated positively with changes in body weight and fat mass (all p < 0.05) and resting HR correlated positively with fasting insulin (p < 0.001) after 12 months. Combining a lifestyle intervention with a high-protein and low-glycemic formula diet improves hemodynamic parameters to a greater extent than lifestyle intervention alone in high-risk individuals with overweight and obesity.
- Find related publications in this database (using NLM MeSH Indexing)
- Blood Pressure - administration & dosage
- Diabetes Mellitus, Type 2 - complications
- Fasting - administration & dosage
- Humans - administration & dosage
- Hypertension - complications, therapy
- Hypoglycemia - administration & dosage
- Obesity - complications
- Overweight - complications, therapy
- Pulse Wave Analysis - administration & dosage
- Find related publications in this database (Keywords)
- blood pressure
- insulin
- lifestyle intervention
- formula diet
- cardiac autonomic regulation
- pulse wave velocity
- heart rate