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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Theiler-Schwetz, V; Trummer, C; Grübler, MR; Keppel, MH; Zittermann, A; Tomaschitz, A; Karras, SN; März, W; Pilz, S; Gängler, S.
Effects of Vitamin D Supplementation on 24-Hour Blood Pressure in Patients with Low 25-Hydroxyvitamin D Levels: A Randomized Controlled Trial.
Nutrients. 2022; 14(7):
Doi: 10.3390/nu14071360
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Pilz Stefan
- Theiler-Schwetz Verena
- Co-authors Med Uni Graz
- Grübler Martin
- Keppel Martin Helmut
- März Winfried
- Tomaschitz Andreas
- Trummer Christian
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- Scite (citation analytics):
- Abstract:
- Accumulating evidence suggests that potential cardiovascular benefits of vitamin D supplementation may be restricted to individuals with very low 25-hydroxyvitamin D (25(OH)D) concentrations; the effect of vitamin D on blood pressure (BP) remains unclear. We addressed this issue in a post hoc analysis of the double-blind, randomized, placebo-controlled Styrian Vitamin D Hypertension Trial (2011-2014) with 200 hypertensive patients with 25(OH)D levels <30 ng/mL. We evaluated whether 2800 IU of vitamin D3/day or placebo (1:1) for 8 weeks affects 24-hour systolic ambulatory BP in patients with 25(OH)D concentrations <20 ng/mL, <16 ng/mL, and <12 ng/mL and whether achieved 25(OH)D concentrations were associated with BP measures. Taking into account correction for multiple testing, p values < 0.0026 were considered significant. No significant treatment effects on 24-hour BP were observed when different baseline 25(OH)D thresholds were used (all p-values > 0.30). However, there was a marginally significant trend towards an inverse association between the achieved 25(OH)D level with 24-hour systolic BP (-0.196 per ng/mL 25(OH)D, 95% CI (-0.325 to -0.067); p = 0.003). In conclusion, we could not document the antihypertensive effects of vitamin D in vitamin D-deficient individuals, but the association between achieved 25(OH)D concentrations and BP warrants further investigations on cardiovascular benefits of vitamin D in severe vitamin D deficiency.
- Find related publications in this database (using NLM MeSH Indexing)
- Blood Pressure - administration & dosage
- Calcifediol - therapeutic use
- Cholecalciferol - administration & dosage
- Dietary Supplements - administration & dosage
- Double-Blind Method - administration & dosage
- Humans - administration & dosage
- Hypertension - administration & dosage
- Vitamin D - analogs & derivatives
- Vitamin D Deficiency - administration & dosage
- Vitamins - administration & dosage
- Find related publications in this database (Keywords)
- blood pressure
- cardiovascular risk
- vitamin D deficiency
- cholecalciferol