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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Haupt, S; Niedrist, T; Sourij, H; Schwarzinger, S; Moser, O.
The Impact of Exercise on Telomere Length, DNA Methylation and Metabolic Footprints.
Cells. 2022; 11(1):
Doi: 10.3390/cells11010153
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Moser Othmar
- Co-authors Med Uni Graz
- Niedrist Tobias Josef
- Sourij Harald
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- Scite (citation analytics):
- Abstract:
- Aging as a major risk factor influences the probability of developing cancer, cardiovascular disease and diabetes, amongst others. The underlying mechanisms of disease are still not fully understood, but research suggests that delaying the aging process could ameliorate these pathologies. A key biological process in aging is cellular senescence which is associated with several stressors such as telomere shortening or enhanced DNA methylation. Telomere length as well as DNA methylation levels can be used as biological age predictors which are able to detect excessive acceleration or deceleration of aging. Analytical methods examining aging are often not suitable, expensive, time-consuming or require a high level of technical expertise. Therefore, research focusses on combining analytical methods which have the potential to simultaneously analyse epigenetic, genomic as well as metabolic changes.
- Find related publications in this database (Keywords)
- telomere length
- DNA methylation
- metabolomics
- exercise
- metabolism