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SHR Neuro Cancer Cardio Lipid Metab Microb
Hirschmugl, B; Wadsack, C.
Transplacental transfer of venlafaxine evaluated by ex vivo perfusion.
Placenta. 2022; 117:150-153
Doi: 10.1016/j.placenta.2021.12.007
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Hirschmugl Birgit
- Wadsack Christian
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- Abstract:
- INTRODUCTION: Depression is frequent among pregnant women and decision for treatment with antidepressants needs careful consideration of risks for the fetus. Since data regarding fetal antidepressant exposure are rare, we aimed to evaluate transplacental transfer of venlafaxine, a selective norepinephrine reuptake inhibitor. METHODS: Ex vivo human placental perfusion experiments were conducted in double closed set-up. Venlafaxine (18.1 ± 2.1 μg/L) was offered in maternal circuit and maternal-to-fetal transfer was monitored over a period of 3h. Venlafaxin and O-desmethylvenlafaxine concentrations were determined by HPLC-MS in maternal and fetal perfusion medium. RESULTS: We observed maternal-to-fetal transfer of venlafaxine within 5 min perfusion. The concentration equilibrium was approximated between maternal (7.5 ± 0.5 μg/L) and fetal (6.5 ± 0.6 μg/L) compartment at time point 180 min, which corresponds to a fetal-maternal (FM) ratio of 0.89. DISCUSSION: Our results are comparable with in vivo data from an observational study which emphasizes that the ex vivo placental perfusion model is suitable for systematic evaluation of fetal antidepressant exposure.
- Find related publications in this database (using NLM MeSH Indexing)
- Female - administration & dosage
- Humans - administration & dosage
- In Vitro Techniques - administration & dosage
- Perfusion - administration & dosage
- Placenta - metabolism
- Pregnancy - administration & dosage
- Serotonin and Noradrenaline Reuptake Inhibitors - pharmacokinetics
- Venlafaxine Hydrochloride - pharmacokinetics
- Find related publications in this database (Keywords)
- Fetal drug exposure
- Antidepressants
- Human serum albumin
- Ex vivo dual placental perfusion