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Michaelis, S; Zelzer, S; Schnedl, WJ; Baranyi, A; Meinitzer, A; Enko, D.
Assessment of tryptophan and kynurenine as prognostic markers in patients with SARS-CoV-2.
Clin Chim Acta. 2022; 525:29-33 Doi: 10.1016/j.cca.2021.12.005 [OPEN ACCESS]
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Co-Autor*innen der Med Uni Graz
Baranyi Andreas
Enko Dietmar
Meinitzer Andreas
Schnedl Wolfgang
Zelzer Sieglinde
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Abstract:
BACKGROUND: Immune dysregulation and inflammation in patients with SARS-CoV-2 is associated with a poor clinical outcome. We investigated the value of the inflammatory markers tryptophan and kynurenine in predicting the survival outcome of patients with SARS-CoV-2. METHODS: The study included 252 inpatients with a SARS-CoV-2 infection hospitalized between August 2020 and April 2021. Two groups were generated based on disease survival (survival group: n = 199; deceased group: n = 53). Plasma concentrations of tryptophan, kynurenine and interleukin-6 (IL-6) were measured on admission. In a subset of patients (n = 105; 81 survivors and 24 deceased) concentrations of tryptophan and kynurenine were checked 7 days after admission. The kynurenine/tryptophan ratio (TRP/KYN ratio) was calculated. RESULTS: On admission, the deceased group showed significantly higher concentrations of kynurenine and a significantly higher KYN/TRP ratio compared to the survival group (p-values < 0.001). Kynurenine and the KYN/TRP ratio significantly correlated with IL-6 (ρ = 0.441 and 0.448, p-values < 0.001). In the survival group, kynurenine and the KYN/TRPratio were significantly lower after seven days (p-values < 0.001). In the deceased group, no significant differences were found between the measurements. CONCLUSION: Kynurenine and the KYN/TRP ratio are potentially useful parameters in predicting the survival outcome in SARS-CoV-2 positive patients.
Find related publications in this database (using NLM MeSH Indexing)
COVID-19 - administration & dosage
Humans - administration & dosage
Kynurenine - administration & dosage
Prognosis - administration & dosage
SARS-CoV-2 - administration & dosage
Tryptophan - administration & dosage

Find related publications in this database (Keywords)
Tryptophan
Kynurenine
SARS-CoV-2
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