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Alhamdan, F; Marsh, LM; Pedersen, F; Alhamwe, BA; Thölken, C; Pfefferle, PI; Bahmer, T; Greulich, T; Potaczek, DP; Garn, H.
Differential Regulation of Interferon Signaling Pathways in CD4+ T Cells of the Low Type-2 Obesity-Associated Asthma Phenotype.
Int J Mol Sci. 2021; 22(18): Doi: 10.3390/ijms221810144 [OPEN ACCESS]
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Co-Autor*innen der Med Uni Graz
Marsh Leigh
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Abstract:
In the era of personalized medicine, insights into the molecular mechanisms that differentially contribute to disease phenotypes, such as asthma phenotypes including obesity-associated asthma, are urgently needed. Peripheral blood was drawn from 10 obese, non-atopic asthmatic adults with a high body mass index (BMI; 36.67 ± 6.90); 10 non-obese, non-atopic asthmatic adults with normal BMI (23.88 ± 2.73); and 10 healthy controls with normal BMI (23.62 ± 3.74). All asthmatic patients were considered to represent a low type-2 asthma phenotype according to selective clinical parameters. RNA sequencing (RNA-Seq) was conducted on peripheral blood CD4+ T cells. Thousands of differentially expressed genes were identified in both asthma groups compared with heathy controls. The expression of interferon (IFN)-stimulated genes associated with IFN-related signaling pathways was specifically affected in obese asthmatics, while the gap junction and G protein-coupled receptor (GPCR) ligand binding pathways were enriched in both asthma groups. Furthermore, obesity gene markers were also upregulated in CD4+ T cells from obese asthmatics compared with the two other groups. Additionally, the enriched genes of the three abovementioned pathways showed a unique correlation pattern with various laboratory and clinical parameters. The specific activation of IFN-related signaling and viral infection pathways might provide a novel view of the molecular mechanisms associated with the development of the low type-2 obesity-associated asthma phenotype, which is a step ahead in the development of new stratified therapeutic approaches.
Find related publications in this database (using NLM MeSH Indexing)
Adult - administration & dosage
Asthma - complications, metabolism
CD4-Positive T-Lymphocytes - metabolism
Cells, Cultured - administration & dosage
Female - administration & dosage
Humans - administration & dosage
Interferons - metabolism
Male - administration & dosage
Middle Aged - administration & dosage
Obesity - complications, metabolism
Receptors, G-Protein-Coupled - metabolism
Signal Transduction - administration & dosage

Find related publications in this database (Keywords)
low type-2 asthma
obesity
asthma phenotypes
CD4(+) T cells
transcriptomics
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