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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schuligoi, R; Grill, M; Heinemann, A; Peskar, BA; Amann, R.
Sequential induction of prostaglandin E and D synthases in inflammation.
BIOCHEM BIOPHYS RES COMMUN. 2005; 335(3): 684-689.
Doi: 10.1016/j.bbrc.2005.07.130
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- Führende Autor*innen der Med Uni Graz
- Schuligoi Rufina
- Co-Autor*innen der Med Uni Graz
- Grill Magdalena
- Heinemann Akos
- Peskar Bernhard
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- Abstract:
- Enhanced biosynthesis of prostaglandin (PG)D(2) and subsequent formation of 15-deoxy-Delta(12,14)-PGJ(2) has been suggested to contribute to resolution of inflammation. The primary aim of the present study in mouse heart was, therefore, to determine at the transcriptional level if there is sequential induction of PGE and PGD synthases (S) during inflammation. Expression of interleukin (IL)-1beta in heart was enhanced 4h after systemic inflammation and declined thereafter within 3-5 days to basal levels. In contrast to cyclooxygenase-2 and membrane-bound (m)-PGES-1, which both peaked 4h after endotoxin administration, hematopoietic (H)-PGDS expression was enhanced only >or=48h after endotoxin. The expression of lipocalin-type (L)-PGDS was not significantly influenced. mRNA encoding the putative target of 15-deoxy-Delta(12,14)-PGJ(2), peroxisome proliferator-activated receptor gamma, was enhanced between 4 and 24h after induction of inflammation. Treatment of mice with acetylsalicylic acid or indomethacin at doses effective to cause near-complete inhibition of PGE(2) and PGD(2) biosynthesis in heart ex vivo resulted in enhanced expression of IL-1beta 24h after endotoxin administration. These results provide additional support for the hypothesis of a shift towards PGD(2) biosynthesis during resolution of inflammation.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Base Sequence -
- Cyclooxygenase 2 -
- DNA Primers -
- Enzyme Induction -
- Inflammation - enzymology
- Interleukin-1 - genetics
- Intramolecular Oxidoreductases - biosynthesis
- Male - biosynthesis
- Mice - biosynthesis
- Mice, Inbred BALB C - biosynthesis
- Myocardium - enzymology
- PPAR gamma - genetics
- Polymerase Chain Reaction - genetics
- Prostaglandin-Endoperoxide Synthases - genetics
- RNA, Messenger - genetics
- Find related publications in this database (Keywords)
- inflammation
- nonsteroidal anti-inflammatory drugs
- prostaglandin D synthase
- prostaglandin E synthase
- peroxisome proliferator-activated receptor gamma