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"Faces" of the day:

Katharina Jandl

Nina Höller

Nariae Baik-Schneditz

Ellen Heitzer

Marianne Brodmann

Ewald Kolesnik

Bernhard Schwaberger

Maximilian Seles

Gabor Toth-Gayor

Lukas Peter Mileder

Niels Hammer

Christian Josef Hill

Christian Viertler

Philipp Klaritsch

Daniel Scherr

Harald Köfeler

Gerhard Pichler

Roland Malli

Michael Fuchsjäger

Gernot Plank

Peter Fickert

Richard Zigeuner

Peter Holzer

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Hady-Cohen, R; Dragoumi, P; Barca, D; Plecko, B; Lerman-Sagie, T; Zafeiriou, D.
Safety and recommendations for vaccinations of children with inborn errors of metabolism
EUR J PAEDIATR NEURO. 2021; 35: 93-99. Doi: 10.1016/j.ejpn.2021.10.002
Web of Science PubMed FullText FullText_MUG

 

Co-authors Med Uni Graz

Plecko Barbara

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Abstract:

Inborn errors of metabolism (IEM) are genetic disorders due to a defective metabolic pathway. The incidence of each disorder is variable and depends on the respective population. Some disorders such as urea cycle disorders (UCD) and organic acidurias, pose a high risk for a metabolic crisis culminating in a life-threatening event, especially during infections; thus, vaccines may play a crucial role in prevention. However, there are different triggers for decompensations including the notion that vaccines themselves can activate fever and malaise. Additionally, many of the IEM include immunodeficiency, placing the patients at an increased risk for infectious diseases and possibly a weaker response to immunizations. Since metabolic crises and vaccine regimens intersect in the first years of life, the question whether to vaccinate the child occupies parents and medical staff. Many metabolic experts hesitate to vaccinate IEM patients, disregarding the higher risk from the direct infections. In this paper we summarize the published data regarding the safety and recommendations for vaccinations in IEM patients, with reference to the risk for decompensations and to the immunogenic component. (c) 2021 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

Find related publications in this database (Keywords)

Inborn errors of metabolism

Neurometabolic

Vaccination

Viruses

Decompensation

Immunodeficiency

Urea cycle disorder

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