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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Herz, CT; Kulterer, OC; Prager, M; Langer, FB; Prager, G; Marculescu, R; Fauler, G; Hacker, M; Kautzky-Willer, A; Trauner, M; Haug, AR; Kiefer, FW.
Characterization of endogenous bile acid composition in individuals with cold-activated brown adipose tissue
MOL CELL ENDOCRINOL. 2021; 536: 111403 Doi: 10.1016/j.mce.2021.111403
Web of Science PubMed FullText FullText_MUG

 

Co-Autor*innen der Med Uni Graz
Fauler Günter
Trauner Michael
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Abstract:
Introduction: Bile acid signaling has been suggested to promote BAT activity in various experimental models. However, little is known if and how physiologic bile acid metabolism is linked to BAT function in humans. Here we investigated the association between BAT activity and circulating bile acid concentrations in lean and obese individuals. Methods: BAT 18F-fluorodeoxyglucose uptake was measured after a standardized cooling protocol by positron emission tomography/computed tomography. Cold-induced thermogenesis was assessed by indirect calorimetry. Fasting bile acid concentrations were determined by high performance liquid chromatography-high-resolution mass spectrometry. Results: In a cohort of 24 BAT-negative and 20 BAT-positive individuals matched by age, sex, and body mass index, circulating bile acid levels were similar between groups except for higher ursodeoxycholic acid and a trend towards a lower 12 alpha-OH/non-12 alpha-OH bile acid ratio in lean participants with active BAT compared to those without. Moreover, the 12 alpha-OH/non-12 alpha-OH ratio, a marker of CYP8B1 activity, correlated negatively with BAT volume and activity. Conclusion: Fasting concentrations of major bile acids are not associated with cold-induced BAT activity in humans. However, the inverse association between BAT activity and 12 alpha-OH/non-12 alpha-OH ratio may suggest CYP8B1 as a potential new target in BAT function and warrants additional investigation.

Find related publications in this database (Keywords)
brown adipose tissue
Bile acids
Thermogenesis
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