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SHR Neuro Cancer Cardio Lipid Metab Microb
Grünig, E; MacKenzie, A; Peacock, AJ; Eichstaedt, CA; Benjamin, N; Nechwatal, R; Ulrich, S; Saxer, S; Bussotti, M; Sommaruga, M; Ghio, S; Gumbiene, L; Palevičiūtė, E; Jurevičienė, E; Cittadini, A; Stanziola, AA; Marra, AM; Kovacs, G; Olschewski, H; Barberà, JA; Blanco, I; Spruit, MA; Franssen, FME; Vonk, Noordegraaf, A; Reis, A; Santos, M; Viamonte, SG; Demeyer, H; Delcroix, M; Bossone, E; Johnson, M.
Standardized exercise training is feasible, safe, and effective in pulmonary arterial and chronic thromboembolic pulmonary hypertension: results from a large European multicentre randomized controlled trial.
Eur Heart J. 2021; 42(23): 2284-2295.
Doi: 10.1093/eurheartj/ehaa696
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PubMed
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- Co-authors Med Uni Graz
- Kovacs Gabor
- Olschewski Horst
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- Abstract:
- AIMS: This prospective, randomized, controlled, multicentre study aimed to evaluate efficacy and safety of exercise training in patients with pulmonary arterial (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). METHODS AND RESULTS: For the first time a specialized PAH/CTEPH rehabilitation programme was implemented in 11 centres across 10 European countries. Out of 129 enrolled patients, 116 patients (58 vs. 58 randomized into a training or usual care control group) on disease-targeted medication completed the study [85 female; mean age 53.6 ± 12.5 years; mean pulmonary arterial pressure 46.6 ± 15.1 mmHg; World Health Organization (WHO) functional class II 53%, III 46%; PAH n = 98; CTEPH n = 18]. Patients of the training group performed a standardized in-hospital rehabilitation with mean duration of 25 days [95% confidence interval (CI) 17-33 days], which was continued at home. The primary endpoint, change of 6-min walking distance, significantly improved by 34.1 ± 8.3 m in the training compared with the control group (95% CI, 18-51 m; P < 0.0001). Exercise training was feasible, safe, and well-tolerated. Secondary endpoints showed improvements in quality of life (short-form health survey 36 mental health 7.3 ± 2.5, P = 0.004), WHO-functional class (training vs. control: improvement 9:1, worsening 4:3; χ2P = 0.027) and peak oxygen consumption (0.9 ± 0.5 mL/min/kg, P = 0.048) compared with the control group. CONCLUSION: This is the first multicentre and so far the largest randomized, controlled study on feasibility, safety, and efficacy of exercise training as add-on to medical therapy in PAH and CTEPH. Within this study, a standardized specialized training programme with in-hospital start was successfully established in 10 European countries.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Aged - administration & dosage
- Chronic Disease - administration & dosage
- Europe - administration & dosage
- Exercise - administration & dosage
- Exercise Tolerance - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Hypertension, Pulmonary - therapy
- Male - administration & dosage
- Middle Aged - administration & dosage
- Prospective Studies - administration & dosage
- Quality of Life - administration & dosage
- Find related publications in this database (Keywords)
- Pulmonary rehabilitation
- Pulmonary hypertension
- Exercise programme