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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Matzhold, EM; Berghold, A; Bemelmans, MKB; Banfi, C; Stelzl, E; Kessler, HH; Steinmetz, I; Krause, R; Wurzer, H; Schlenke, P; Wagner, T.
Lewis and ABO histo-blood types and the secretor status of patients hospitalized with COVID-19 implicate a role for ABO antibodies in susceptibility to infection with SARS-CoV-2.
Transfusion. 2021; 61(9):2736-2745
Doi: 10.1111/trf.16567
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Matzhold Eva-Maria
- Co-authors Med Uni Graz
- Banfi Chiara
- Berghold Andrea
- Kessler Harald
- Krause Robert
- Schlenke Peter
- Steinmetz Ivo
- Stelzl Evelyn
- Wagner Thomas
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- Scite (citation analytics):
- Abstract:
- BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targets the respiratory and gastric epithelium, causing coronavirus disease 2019 (COVID-19). Tissue antigen expression variations influence host susceptibility to many infections. This study aimed to investigate the closely linked Lewis (FUT3) and ABO histo-blood types, including secretor (FUT2) status, to infections with SARS-CoV-2 and the corresponding severity of COVID-19. STUDY DESIGN AND METHODS: Patients (Caucasians, n = 338) were genotyped for ABO, FUT3, and FUT2, and compared to a reference population of blood donors (n = 250,298). The association between blood types and severity of COVID-19 was addressed by dividing patients into four categories: hospitalized individuals in general wards, patients admitted to the intensive care unit with and without intubation, and deceased patients. Comorbidities were considered in subsequent analyses. RESULTS: Patients with blood type Lewis (a-b-) or O were significantly less likely to be hospitalized (odds ratio [OR] 0.669, confidence interval [CI] 0.446-0.971, OR 0.710, CI 0.556-0.900, respectively), while type AB was significantly more prevalent in the patient cohort (OR 1.519, CI 1.014-2.203). The proportions of secretors/nonsecretors, and Lewis a+ or Lewis b+ types were consistent between patients and controls. The analyzed blood groups were not associated with the clinical outcome as defined. DISCUSSION: Blood types Lewis (a-b-) and O were found to be protective factors, whereas the group AB is suggested to be a risk factor for COVID-19. The antigens investigated may not be prognostic for disease severity, but a role for ABO isoagglutinins in SARS-CoV-2 infections is strongly suggested.
- Find related publications in this database (using NLM MeSH Indexing)
- ABO Blood-Group System - immunology
- Adult - administration & dosage
- Aged - administration & dosage
- Aged, 80 and over - administration & dosage
- COVID-19 - blood, epidemiology, etiology
- Comorbidity - administration & dosage
- Disease Susceptibility - administration & dosage
- Female - administration & dosage
- Host-Pathogen Interactions - immunology
- Humans - administration & dosage
- Lewis Blood Group Antigens - immunology
- Male - administration & dosage
- Middle Aged - administration & dosage
- Odds Ratio - administration & dosage
- Public Health Surveillance - administration & dosage
- SARS-CoV-2 - immunology
- Young Adult - administration & dosage
- Find related publications in this database (Keywords)
- ABO
- COVID-19
- host-pathogen interaction
- Lewis
- secretor