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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Camp, JV; Schmon, E; Krause, R; Sixl, W; Schmid, D; Aberle, SW.
Genetic Diversity of Puumala orthohantavirus in Rodents and Human Patients in Austria, 2012-2019.
VIRUSES-BASEL. 2021; 13(4):
Doi: 10.3390/v13040640
[OPEN ACCESS]
Web of Science
PubMed
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FullText_MUG
- Co-authors Med Uni Graz
- Krause Robert
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- Abstract:
- Puumala orthohantavirus (PUUV) has a wide distribution throughout Europe. Distinctive temporal patterns of spillover into the human population are related to population dynamics of the reservoir host, the bank vole (Clethrionomys glareolus). As the rodent host is tied to specific habitats with small individual ranges, PUUV genetic diversity is also highly correlated with geographic distance. Using sequenced portions of viral S and M segments, we determined whether geographic clusters were supported. Human cases of PUUV infections are concentrated in southeastern Austria. We detected four distinct genotypes: two genotypes of the Alpe-Adria (ALAD) lineage typically associated with southeast Europe, and two sublineages of the Central Europe (CE) lineage. One cluster of CE genotypes represents a phylogenetically distinct sublineage compared to previously reported CE clades, and extends the boundary of the CE lineage further south than previously reported.
- Find related publications in this database (Keywords)
- hantavirus
- Puumala orthohantavirus
- genetic diversity
- phylogeography
- molecular epidemiology