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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Knuplez, E; Sturm, EM; Marsche, G.
Emerging Role of Phospholipase-Derived Cleavage Products in Regulating Eosinophil Activity: Focus on Lysophospholipids, Polyunsaturated Fatty Acids and Eicosanoids.
Int J Mol Sci. 2021; 22(9):
Doi: 10.3390/ijms22094356
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Gruden Eva
- Marsche Gunther
- Co-authors Med Uni Graz
- Böhm Eva
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- Abstract:
- Eosinophils are important effector cells involved in allergic inflammation. When stimulated, eosinophils release a variety of mediators initiating, propagating, and maintaining local inflammation. Both, the activity and concentration of secreted and cytosolic phospholipases (PLAs) are increased in allergic inflammation, promoting the cleavage of phospholipids and thus the production of reactive lipid mediators. Eosinophils express high levels of secreted phospholipase A2 compared to other leukocytes, indicating their direct involvement in the production of lipid mediators during allergic inflammation. On the other side, eosinophils have also been recognized as crucial mediators with regulatory and homeostatic roles in local immunity and repair. Thus, targeting the complex network of lipid mediators offer a unique opportunity to target the over-activation and 'pro-inflammatory' phenotype of eosinophils without compromising the survival and functions of tissue-resident and homeostatic eosinophils. Here we provide a comprehensive overview of the critical role of phospholipase-derived lipid mediators in modulating eosinophil activity in health and disease. We focus on lysophospholipids, polyunsaturated fatty acids, and eicosanoids with exciting new perspectives for future drug development.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Eicosanoids - metabolism
- Eosinophils - immunology, metabolism, pathology
- Fatty Acids, Unsaturated - metabolism
- Humans - administration & dosage
- Lysophospholipids - metabolism
- Phospholipases - metabolism
- Find related publications in this database (Keywords)
- eosinophils
- phospholipase
- lipid mediators
- arachidonic acid
- eicosanoids
- prostaglandins
- leukotrienes
- lysophospholipids
- endocannabinoids