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Zittermann, A; Trummer, C; Theiler-Schwetz, V; Lerchbaum, E; März, W; Pilz, S.
Vitamin D and Cardiovascular Disease: An Updated Narrative Review.
Int J Mol Sci. 2021; 22(6): 2896 Doi: 10.3390/ijms22062896 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Führende Autor*innen der Med Uni Graz
Pilz Stefan
Co-Autor*innen der Med Uni Graz
Lerchbaum Elisabeth
März Winfried
Theiler-Schwetz Verena
Trummer Christian
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Abstract:
During the last two decades, the potential impact of vitamin D on the risk of cardiovascular disease (CVD) has been rigorously studied. Data regarding the effect of vitamin D on CVD risk are puzzling: observational data indicate an inverse nonlinear association between vitamin D status and CVD events, with the highest CVD risk at severe vitamin D deficiency; however, preclinical data and randomized controlled trials (RCTs) show several beneficial effects of vitamin D on the surrogate parameters of vascular and cardiac function. By contrast, Mendelian randomization studies and large RCTs in the general population and in patients with chronic kidney disease, a high-risk group for CVD events, largely report no significant beneficial effect of vitamin D treatment on CVD events. In patients with rickets and osteomalacia, cardiovascular complications are infrequently reported, except for an increased risk of heart failure. In conclusion, there is no strong evidence for beneficial vitamin D effects on CVD risk, either in the general population or in high-risk groups. Whether some subgroups such as individuals with severe vitamin D deficiency or a combination of low vitamin D status with specific gene variants and/or certain nutrition/lifestyle factors would benefit from vitamin D (metabolite) administration, remains to be studied.

Find related publications in this database (Keywords)
vitamin D
cardiovascular
heart
atherosclerosis
epidemiology
vitamin D receptor
mortality
chronic kidney disease
calcium
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