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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Fallah, S; Marsche, G; Mohamadinarab, M; Mohassel Azadi, S; Ghasri, H; Fadaei, R; Moradi, N.
Impaired cholesterol efflux capacity in patients with Helicobacter pylori infection and its relation with inflammation.
J Clin Lipidol. 2020; 15(1):218-226 Doi: 10.1016/j.jacl.2020.11.005
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Co-Autor*innen der Med Uni Graz
Marsche Gunther
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Abstract:
Gut microorganisms are associated with atherosclerosis and related cardiovascular disease. Helicobacter pylori (H. pylori) infection is associated with dyslipidemia and inflammation contributing to the progression of atherosclerosis. Several studies have reported reduced HDL-C levels in H. pylori infected patients, but HDL cholesterol efflux capacity (CEC) as the most important function of HDL has not been evaluated yet. This cross-sectional study was conducted with 44 biopsy confirmed H. pylori patients and 43 controls. ABCA1-mediated, non-ABCA1 and total CEC were measured in ApoB-depleted serum and levels of ApoA-I, ApoB and hsCRP were estimated using ELISA technique. Total and ABCA1 mediated-CEC were reduced in patients compared to controls, independent of age, sex, body mass index and HDL-C (p < 0.001), while non-ABCA1 CEC indicated no significant change between the groups. In addition, patients showed lower serum levels of ApoA-I but increased levels of hsCRP when compared to controls. Total CEC and ABCA1-mediated CEC positively correlated with ApoA-I and HDL-C, furthermore, ABCA1-mediated CEC as well as ApoA-I inversely correlated with hsCRP. The results of the present study indicate reduced CECs in H. pylori infected patients, especially ABCA1-mediated CEC which is associated with decreased ApoA-I and increased inflammation. Copyright © 2020 National Lipid Association. Published by Elsevier Inc. All rights reserved.

Find related publications in this database (Keywords)
Cholesterol efflux capacity
HDL function
Inflammation
Infection
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