Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Navigation/Suche
- Forscher*innen
- Institutionen
- Projekte
- Publikationen
- Partner
- Geldgeber
- Ausstattung
- Knowhow
- Forschungsfelder
"Köpfe" der aktuellen Meldungen:
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schalli, M; Weber, P; Nasseri, SA; Gomez, AT; Muller, P; Stutz, AE; Withers, SG; Wolfsgruber, A; Wrodnigg, TM.
Biologically active branched-chain aminocyclopentane tetraols from d-galactose
MONATSH CHEM. 2019; 150(5): 861-870.
Doi: 10.1007/s00706-019-02428-0
Web of Science
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Schalli Michael
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- From 1,2;3,4-di-O-isopropylidene-d-galactopyranose, a series of highly functionalized branched-chain cyclopentanes was easily available. The initial partially protected cyclopentane tetraol is a versatile central intermediate and was exploited as subject to various highly regio- and stereoselective structural alterations with a view to prepare selective -d-galactosidase inhibitors. In line with our findings on recently reported constitutional isomers featuring amino substituents, basic derivatives are medium activity inhibitors of -d-galactosidases with side activities for beta-glucosidases. [GRAPHICS] .
- Find related publications in this database (Keywords)
- Aminoalcohols
- Carbocycles
- Carbohydrates
- Cyclizations
- Ene reactions
- Structure-activity relationships