Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Navigation/Suche
- Forscher*innen
- Institutionen
- Projekte
- Publikationen
- Partner
- Geldgeber
- Ausstattung
- Knowhow
- Forschungsfelder
"Köpfe" der aktuellen Meldungen:
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zoidl, M; Wolfsgruber, A; Schalli, M; Nasseri, SA; Weber, P; Stütz, AE; Withers, SG; Wrodnigg, TM.
Synthesis of modified 1,5-imino-d-xylitols as ligands for lysosomal β-glucocerebrosidase.
Monatsh Chem. 2019; 150(5): 831-842.
Doi: 10.1007/s00706-019-02427-1
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Schalli Michael
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Modified 1,5-dideoxy-1,5-imino-d-xylitol analogues with different substitution patterns involving position C-1 and/or the ring nitrogen were prepared, which were designed to serve as precursors for the preparation of iminoxylitol-based ligands and tools for the elucidation and modulation of human lysosomal β-glucocerebrosidase. Biological evaluation of the synthesized glycomimetics with a series of glycoside hydrolases revealed that these substitution patterns elicit excellent β-glucosidase selectivities.
- Find related publications in this database (Keywords)
- Carbohydrates
- Conformation
- Enzymes
- -Glucosidase ligands
- Iminoxylitol
- -Glucocerebrosidase