Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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"Köpfe" der aktuellen Meldungen:

Nina Höller

Nariae Baik-Schneditz

Bernhard Schwaberger

Lukas Peter Mileder

Niels Hammer

Gerhard Pichler

Roland Malli

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Katzmann, JL; Werner, CM; Stojakovic, T; März, W; Scharnagl, H; Laufs, U.
Apolipoprotein CIII predicts cardiovascular events in patients with coronary artery disease: a prospective observational study.
Lipids Health Dis. 2020; 19(1):116-116 Doi: 10.1186/s12944-020-01293-9 [OPEN ACCESS]
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Co-Autor*innen der Med Uni Graz: März Winfried; Scharnagl Hubert; Stojakovic Tatjana
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Abstract:: Apolipoprotein CIII (apoCIII) is associated with triglyceride-rich lipoprotein metabolism and has emerged as independent marker for risk of cardiovascular disease. The objective was to test whether apoCIII is regulated postprandially and whether apoCIII concentrations in native and chylomicron-free serum predict future cardiovascular events in patients with stable coronary artery disease (CAD). ApoCIII concentrations were measured in native and chylomicron-free serum in the fasting state and after a standardized oral fat load test in 195 patients with stable CAD. Clinical follow-up was 48 months. Chylomicron-free serum was prepared by ultracentrifugation (18,000 rpm, 3 h). The log-rank test and Cox regression analyses were used to investigate the association of apoCIII with recurrent cardiovascular events. Of the 195 patients included, 92 had a cardiovascular event, and 103 did not. 97% were treated with a statin. No significant changes in apoCIII concentration were observed after the oral fat load test. The apoCIII concentration was associated with event-free survival independent of conventional risk factors. This association reached statistical significance only for apoCIII concentration measured in chylomicron-free serum (hazard ratio [95% confidence interval] for apoCIII above the mean: postprandial: 1.67 (1.06-2.29), P = 0.028, fasting: 2.09 (1.32-3.32), P = 0.002), but not for apoCIII concentration measured in native serum (postprandial: 1.47 [0.89-2.43], P = 0.133, fasting: 1.56 [0.95-2.58], P = 0.081). The effects were independent of other risk factors. ApoCIII concentrations in chylomicron-free serum are independently associated with event-free survival in patients with CAD both in fasting and postprandial state. This findings support considering apoCIII for risk assessment and attempting to test the hypothesis that lowering apoCIII reduces residual cardiovascular risk. Apolipoprotein CIII concentration measured in chylomicron-free serum predicts recurrent cardiovascular events in patients with stable coronary artery disease. The trial which included the participants of this study was registered at https://clinicaltrials.gov (NCT00628524) on March 5, 2008.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Adult -; Aged -; Apolipoprotein C-III - blood; Apolipoprotein C-III - genetics; Apolipoproteins C - blood; Cardiovascular Diseases - blood; Cardiovascular Diseases - drug therapy; Coronary Artery Disease - blood; Coronary Artery Disease - drug therapy; Female -; Humans -; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Lipoproteins - blood; Male -; Middle Aged -; Postprandial Period -; Prospective Studies -; Risk Factors -; Triglycerides - blood; Waist-Hip Ratio - methods; Young Adult -
Find related publications in this database (Keywords): Apolipoprotein CIII; Chylomicron; Cardiovascular disease; Coronary artery disease; Risk factor; Antisense oligonucleotide; Triglyceride; Ultracentrifugation; Oral fat tolerance test