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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Gutiérrez, T; Qi, H; Yap, MC; Tahbaz, N; Milburn, LA; Lucchinetti, E; Lou, PH; Zaugg, M; LaPointe, PG; Mercier, P; Overduin, M; Bischof, H; Burgstaller, S; Malli, R; Ballanyi, K; Shuai, J; Simmen, T.
The ER chaperone calnexin controls mitochondrial positioning and respiration.
Sci Signal. 2020; 13(638):
Doi: 10.1126/scisignal.aax6660
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Bischof Helmut
- Burgstaller Sandra
- Malli Roland
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- Abstract:
- Chaperones in the endoplasmic reticulum (ER) control the flux of Ca2+ ions into mitochondria, thereby increasing or decreasing the energetic output of the oxidative phosphorylation pathway. An example is the abundant ER lectin calnexin, which interacts with sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). We found that calnexin stimulated the ATPase activity of SERCA by maintaining its redox state. This function enabled calnexin to control how much ER Ca2+ was available for mitochondria, a key determinant for mitochondrial bioenergetics. Calnexin-deficient cells compensated for the loss of this function by partially shifting energy generation to the glycolytic pathway. These cells also showed closer apposition between the ER and mitochondria. Calnexin therefore controls the cellular energy balance between oxidative phosphorylation and glycolysis. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.