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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Smole, U; Gour, N; Phelan, J; Hofer, G; Köhler, C; Kratzer, B; Tauber, PA; Xiao, X; Yao, N; Dvorak, J; Caraballo, L; Puerta, L; Rosskopf, S; Chakir, J; Malle, E; Lane, AP; Pickl, WF; Lajoie, S; Wills-Karp, M.
Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity.
Nat Immunol. 2020; 21(7):756-765
Doi: 10.1038/s41590-020-0698-1
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- Co-Autor*innen der Med Uni Graz
- Malle Ernst
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- Abstract:
- The molecular basis for the propensity of a small number of environmental proteins to provoke allergic responses is largely unknown. Herein, we report that mite group 13 allergens of the fatty acid-binding protein (FABP) family are sensed by an evolutionarily conserved acute-phase protein, serum amyloid A1 (SAA1), that promotes pulmonary type 2 immunity. Mechanistically, SAA1 interacted directly with allergenic mite FABPs (Der p 13 and Blo t 13). The interaction between mite FABPs and SAA1 activated the SAA1-binding receptor, formyl peptide receptor 2 (FPR2), which drove the epithelial release of the type-2-promoting cytokine interleukin (IL)-33 in a SAA1-dependent manner. Importantly, the SAA1-FPR2-IL-33 axis was upregulated in nasal epithelial cells from patients with chronic rhinosinusitis. These findings identify an unrecognized role for SAA1 as a soluble pattern recognition receptor for conserved FABPs found in common mite allergens that initiate type 2 immunity at mucosal surfaces.