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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Reinisch, I; Schreiber, R; Prokesch, A.
Regulation of thermogenic adipocytes during fasting and cold.
Mol Cell Endocrinol. 2020; 512: 110869
Doi: 10.1016/j.mce.2020.110869
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Prokesch Andreas
- Reinisch Isabel Nadine
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- Abstract:
- Cold exposure activates brown and brown-like adipocytes that dissipate large amounts of glucose and fatty acids via uncoupling protein 1 (UCP1) to drive non-shivering thermogenesis (NST). Evidence for the existence of these thermogenic adipocytes in adult humans gave rise to a renaissance in research on brown adipose tissue, establishing it as linchpin of energy homeostasis and metabolic health. Besides low ambient temperature, shortage or excess of food affect thermoregulation. Upon high caloric meals thermogenic adipocytes burn excess calories and maintain energy balance. In contrast, in conditions of nutrient deprivation, counter-regulatory mechanisms prevent thermogenic adipocytes from "wasting" energy substrates that need to be conserved. In this review, we discuss cell-autonomous mechanisms, metabolites, and hormones that modify NST in response to nutrient fluctuations. In particular, we focus on how thermogenic adipocytes balance thermogenesis with systemic energy homeostasis during fasting periods.
- Find related publications in this database (using NLM MeSH Indexing)
- Adaptation, Physiological - physiology
- Adipocytes - physiology
- Adipose Tissue, Brown - physiology
- Animals - administration & dosage
- Body Temperature Regulation - physiology
- Cold Temperature - administration & dosage
- Energy Metabolism - physiology
- Fasting - metabolism
- Humans - administration & dosage
- Hypothermia - metabolism, physiopathology
- Thermogenesis - physiology
- Find related publications in this database (Keywords)
- Non-shivering thermogenesis
- Thermogenic adipocytes
- Brown adipose tissue
- Browning
- Fasting
- Starvation