Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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"Köpfe" der aktuellen Meldungen:

Nina Höller

Nariae Baik-Schneditz

Bernhard Schwaberger

Lukas Peter Mileder

Niels Hammer

Gerhard Pichler

Roland Malli

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Safari, Z; Bruneau, A; Monnoye, M; Mariadassou, M; Philippe, C; Zatloukal, K; Gérard, P.
Murine Genetic Background Overcomes Gut Microbiota Changes to Explain Metabolic Response to High-Fat Diet.
Nutrients. 2020; 12(2): Doi: 10.3390/nu12020287 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Führende Autor*innen der Med Uni Graz: Safari Zahra; Zatloukal Kurt
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Abstract:: Interactions of diet, gut microbiota, and host genetics play essential roles in the development of metabolic diseases. A/J and C57BL/6J (C57) are two mouse strains known to display different susceptibilities to metabolic disorders. In this context, we analyzed gut microbiota composition in A/J and C57 mice, and assessed its responses to high-fat diet (HFD) and antibiotic (AB) treatment. We also exchanged the gut microbiota between the two strains following AB treatment to evaluate its impact on the metabolism. We showed that A/J and C57 mice have different microbiome structure and composition at baseline. Moreover, A/J and C57 microbiomes responded differently to HFD and AB treatments. Exchange of the gut microbiota between the two strains was successful as recipients' microbiota resembled donor-strain microbiota. Seven weeks after inoculation, the differences between recipients persisted and were still closer from the donor-strain microbiota. Despite effective microbiota transplants, the response to HFD was not markedly modified in C57 and A/J mice. Particularly, body weight gain and glucose intolerance in response to HFD remained different in the two mouse strains whatever the changes in microbiome composition. This indicated that genetic background has a much stronger impact on metabolic responses to HFD than gut microbiome composition.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Anti-Bacterial Agents - pharmacology; Diet, High-Fat - adverse effects; Gastrointestinal Microbiome - genetics; Genetic Background -; Genetic Predisposition to Disease - genetics; Metabolic Diseases - etiology; Metabolic Diseases - genetics; Metabolic Diseases - microbiology; Mice -; Mice, Inbred C57BL -
Find related publications in this database (Keywords): fecal microbiota transplantation (FMT); antibiotic treatment; high-fat diet (HFD); genetic background; metabolic disease; non-alcoholic fatty liver disease (NAFLD)