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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Knuplez, E; Curcic, S; Theiler, A; Bärnthaler, T; Trakaki, A; Trieb, M; Holzer, M; Heinemann, A; Zimmermann, R; Sturm, EM; Marsche, G.
Lysophosphatidylcholines inhibit human eosinophil activation and suppress eosinophil migration in vivo.
Biochim Biophys Acta Mol Cell Biol Lipids. 2020; 1865(7):158686-158686
Doi: 10.1016/j.bbalip.2020.158686
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- Führende Autor*innen der Med Uni Graz
- Gruden Eva
- Marsche Gunther
- Co-Autor*innen der Med Uni Graz
- Bärnthaler Thomas
- Böhm Eva
- Curcic Sanja
- Heinemann Akos
- Holzer Michael
- Theiler Anna
- Trakaki Athina
- Trieb Markus
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- Abstract:
- Eosinophils are important multifaceted effector cells involved in allergic inflammation. Following allergen challenge, eosinophils and other immune cells release secreted phospholipases, generating lysophosphatidylcholines (LPCs). LPCs are potent lipid mediators, and serum levels of LPCs associate with asthma severity, suggesting a regulatory activity of LPCs in asthma development. As of yet, the direct effects of LPCs on eosinophils remain unclear. In the present study, we tested the effects of the major LPC species (16:0, 18:0 and 18:1) on eosinophils isolated from healthy human donors. Addition of saturated LPCs in the presence of albumin rapidly disrupted cholesterol-rich nanodomains on eosinophil cell membranes and suppressed multiple eosinophil effector responses, such as CD11b upregulation, degranulation, chemotaxis, and downstream signaling. Furthermore, we demonstrate in a mouse model of allergic cell recruitment, that LPC treatment markedly reduces immune cell infiltration into the lungs. Our observations suggest a strong modulatory activity of LPCs in the regulation of eosinophilic inflammation in vitro and in vivo. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
- Find related publications in this database (Keywords)
- Secreted phospholipase
- Lysophospholipids
- Lipid rafts
- Allergic inflammation