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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wagner, M; Fickert, P.
Drug Therapies for Chronic Cholestatic Liver Diseases.
Annu Rev Pharmacol Toxicol. 2020; 60(1):503-527
Doi: 10.1146/annurev-pharmtox-010818-021059
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- Führende Autor*innen der Med Uni Graz
- Wagner Martin
- Co-Autor*innen der Med Uni Graz
- Fickert Peter
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- Abstract:
- Though ursodeoxycholic acid (UDCA) remains the baseline treatment for most cholestatic liver diseases, UDCA treatment leaves approximately one-third of patients with primary biliary cholangitis (PBC) and all patients with primary sclerosing cholangitis (PSC) at risk for disease progression. New anticholestatic agents, including nuclear receptor agonists, choleretics, and bile acid synthesis suppressors, will likely increase response rates to therapy in PBC and PSC. Strategies that target early immune-mediated injury have so far been disappointing, hampered by the lack of biomarkers to detect early disease states, which then could profit from immunomodulatory therapy. Future concepts need to personalize treatments according to disease stage, progression, and phase, and to combine multiple drugs to target different pathogenic pathways.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cholagogues and Choleretics - pharmacology
- Cholagogues and Choleretics - therapeutic use
- Cholangitis, Sclerosing - drug therapy
- Cholangitis, Sclerosing - physiopathology
- Cholestasis - drug therapy
- Cholestasis - physiopathology
- Chronic Disease -
- Disease Progression -
- Humans -
- Liver Cirrhosis, Biliary - drug therapy
- Liver Cirrhosis, Biliary - physiopathology
- Receptors, Cytoplasmic and Nuclear - agonists
- Ursodeoxycholic Acid - therapeutic use
- Find related publications in this database (Keywords)
- primary biliary cholangitis
- primary sclerosing cholangitis
- ursodeoxycholic acid
- obeticholic acid