Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Curcic, S; Tiapko, O; Groschner, K.
Photopharmacology and opto-chemogenetics of TRPC channels-some therapeutic visions.
PHARMACOL THERAPEUT. 2019; 200(5): 13-26. Doi: 10.1016/j.pharmthera.2019.04.003 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Führende Autor*innen der Med Uni Graz
Curcic Sanja
Groschner Klaus
Co-Autor*innen der Med Uni Graz
Tiapko Oleksandra
Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:
Non-selective cation conductances formed by transient receptor potential canonical (TRPC) proteins govern the function and fate of a wide range of human cell types. In the past decade, evidence has accumulated for a pivotal role of these channels in human diseases, raising substantial interest in their therapeutic targeting. As yet, an appreciable number of small molecules for block and modulation of recombinant TRPC conductances have been identified. However, groundbreaking progress in TRPC pharmacology towards therapeutic applications is lagging behind due to incomplete understanding of their molecular pharmacology and their exact role in disease. A major breakthrough that is expected to overcome these hurdles is the recent success in obtaining high-resolution structure information on TRPC channel complexes and the advent of TRP photopharmacology and optogenetics. Here, we summarize current concepts of enhancing the precision of therapeutic interference with TRPC signaling and TRPC-mediated pathological processes. Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Find related publications in this database (Keywords)
TRPC channels
Photopharmacology
Photochromic ligands
Chemogenetic manipulation
TRPC pathophysiology
© Med Uni Graz • Impressum