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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stekovic, S; Hofer, SJ; Tripolt, N; Aon, MA; Royer, P; Pein, L; Stadler, JT; Pendl, T; Prietl, B; Url, J; Schroeder, S; Tadic, J; Eisenberg, T; Magnes, C; Stumpe, M; Zuegner, E; Bordag, N; Riedl, R; Schmidt, A; Kolesnik, E; Verheyen, N; Springer, A; Madl, T; Sinner, F; de Cabo, R; Kroemer, G; Obermayer-Pietsch, B; Dengjel, J; Sourij, H; Pieber, TR; Madeo, F.
Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans.
Cell Metab. 2019; 30(3):462-476
Doi: 10.1016/j.cmet.2019.07.016
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- Co-Autor*innen der Med Uni Graz
- Bordag Natalie
- Kolesnik Ewald
- Madl Tobias
- Obermayer-Pietsch Barbara
- Pein Lukas
- Pieber Thomas
- Prietl Barbara
- Riedl Regina
- Schmidt Albrecht
- Sinner Frank Michael
- Sourij Harald
- Springer Anna Maria
- Stadler Julia
- Tripolt Norbert
- Verheyen Nicolas Dominik
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- Abstract:
- Caloric restriction and intermittent fasting are known to prolong life- and healthspan in model organisms, while their effects on humans are less well studied. In a randomized controlled trial study (ClinicalTrials.gov identifier: NCT02673515), we show that 4 weeks of strict alternate day fasting (ADF) improved markers of general health in healthy, middle-aged humans while causing a 37% calorie reduction on average. No adverse effects occurred even after >6 months. ADF improved cardiovascular markers, reduced fat mass (particularly the trunk fat), improving the fat-to-lean ratio, and increased β-hydroxybutyrate, even on non-fasting days. On fasting days, the pro-aging amino-acid methionine, among others, was periodically depleted, while polyunsaturated fatty acids were elevated. We found reduced levels sICAM-1 (an age-associated inflammatory marker), low-density lipoprotein, and the metabolic regulator triiodothyronine after long-term ADF. These results shed light on the physiological impact of ADF and supports its safety. ADF could eventually become a clinically relevant intervention. Copyright © 2019 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- 3-Hydroxybutyric Acid - blood
- Adult -
- Aging - blood
- Biomarkers - blood
- Body Mass Index -
- Caloric Restriction - adverse effects
- Energy Intake - physiology
- Fasting - adverse effects
- Fasting - blood
- Fatty Acids, Unsaturated - blood
- Female -
- Healthy Aging - blood
- Healthy Volunteers -
- Humans -
- Intercellular Adhesion Molecule-1 - blood
- Lipoproteins, LDL - blood
- Male -
- Middle Aged -
- Pilot Projects -
- Prospective Studies -
- Triiodothyronine - blood
- Weight Loss -